Optical tomography of the breast using a multi-channel time-resolved imager

Yates, Tara D.; Hebden, Jeremy C.; Gibson, Adam; Everdell, Nick; Arridge, Simon; Douek, Michael

doi:10.1088/0031-9155/50/11/005

Cited by 97 publications

(85 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Intra-and interobserver agreement were good to excellent, indicating a reproducible method. Our results are in agreement with previously published studies using different techniques [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Detection rates ranging from 0.04 to 1.00 were reported, irrespective of lesion classification (benign/malignant).…”

Section: Discussionsupporting

confidence: 93%

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

et al. 2009

View full text Add to dashboard Cite

This paper presents an evaluation of a prototype diffuse optical tomography (DOT) system. Seventeen women with 18 breast lesions (10 invasive carcinomas, 2 fibroadenomas, and 6 benign cysts; diameters 13-54 mm) were evaluated with DOT and magnetic resonance imaging (MRI). A substantial fraction of the original 36 recruited patients could not be examined using this prototype due to technical problems. A region of interest (ROI) was drawn at the lesion position as derived from MRI and at the mirror image site in the contralateral healthy breast. ROIs were assessed quantitatively and qualitatively by two observers independently in two separate readings. Intra-and interobserver agreements were calculated using kappa statistics (k) and intraclass correlation coefficients (ICCs). Discriminatory values for presence of malignancy were determined by receiver operating characteristic (ROC) analyses. Intraobserver agreements were excellent (k 0.88 and 0.88; ICC 0.978 and 0.987), interobserver agreements were good to excellent (k 0.77-0.95; ICC 0.96-0.98). Discriminatory values for presence of malignancy were 0.92-0.93 and 0.97-0.99 for quantitative and qualitative ROC analysis, respectively. This DOT system has the potential to discriminate malignant from benign breast tissue in a reproducible qualitative and quantitative manner. Important technical improvements are required before this technique is ready for clinical application.

show abstract

Section: Discussionsupporting

confidence: 93%

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

et al. 2009

View full text Add to dashboard Cite

show abstract

“…19, 20, and 21), but there are also the systems, employing continuous (cw) laser radiation (cwmammographs, Ref. 22), whereas time-domain instruments [23][24][25] use ultrashort laser pulses as an input. The latter systems gauge the temporal dispersion of the transmitted laser pulse by recording temporal point spread functions at a resolution of typically tens to hundreds of picoseconds.…”

Section: Overview On Methods Of Optical Mammographymentioning

confidence: 99%

Detection and characterization of breast tumours by time-domain scanning optical mammography

Rinneberg

Grosenick

Moesta

et al. 2008

Opto-Electronics Review

View full text Add to dashboard Cite

The paper gives a short overview of various methods of optical mammography, emphasizing scanning time-domain mammography. The results of a clinical study on time-domain optical mammography are reviewed, comprising 154 patients carrying a total of 102 carcinomas validated by histology. A visibility score attributed to each carcinoma as qualitative measure of tumour detectability indicates acceptable sensitivity but poor specificity for discrimination between malignant and benign lesions. Likewise, a multi-variate statistical analysis yields sensitivity and specificity between 80% and 85% for tumour detection and discrimination with respect to normal (healthy) breast tissue, but values less than 70% for discrimination between malignant and benign breast lesions, being too low to be of clinical relevance. For 87 of the 88 tumours detected retrospectively in both projection optical mammograms, optical properties and tissue parameters were derived based on the diffraction of photon density waves by a spherical inhomogeneity as forward model. Following injection of a bolus of indocyanine green as non-targeted absorbing contrast agent, dynamic contrast-enhanced time-domain optical mammography was carried out on a small number of patients, but no differences in wash-out kinetics of indocyanine green between tumours and healthy breast tissue were observed.

show abstract

“…We assumed that the medium was a 2D square with a 50 mm side which had l 0 s ¼ 0:8 mm À1 and l a ¼ 0:0023 mm À1 [34] as the background. The probe measured the PA pressure waves at 11 positions of x ¼ À10; À8; .…”

Section: D Pde-based Linearized Image Reconstruction Algorithmmentioning

confidence: 99%

Effects of the approximations of light propagation on quantitative photoacoustic tomography using two-dimensional photon diffusion equation and linearization

Okawa

Hirasawa

Kubota

et al. 2017

Opt Rev

View full text Add to dashboard Cite

Quantitative photoacoustic tomography (QPAT) employing a light propagation model will play an important role in medical diagnoses by quantifying the concentration of hemoglobin or a contrast agent. However, QPAT by the light propagation model with the three-dimensional (3D) radiative transfer equation (RTE) requires a huge computational load in the iterative forward calculations involved in the updating process to reconstruct the absorption coefficient. The approximations of the light propagation improve the efficiency of the image reconstruction for the QPAT. In this study, we compared the 3D/ two-dimensional (2D) photon diffusion equation (PDE) approximating 3D RTE with the Monte Carlo simulation based on 3D RTE. Then, the errors in a 2D PDE-based linearized image reconstruction caused by the approximations were quantitatively demonstrated and discussed in the numerical simulations. It was clearly observed that the approximations affected the reconstructed absorption coefficient. The 2D PDE-based linearized algorithm succeeded in the image reconstruction of the region with a large absorption coefficient in the 3D phantom. The value reconstructed in the phantom experiment agreed with that in the numerical simulation, so that it was validated that the numerical simulation of the image reconstruction predicted the relationship between the true absorption coefficient of the target in the 3D medium and the reconstructed value with the 2D PDE-based linearized algorithm. Moreover, the the true absorption coefficient in 3D medium was estimated from the 2D reconstructed image on the basis of the prediction by the numerical simulation. The estimation was successful in the phantom experiment, although some limitations were revealed.

show abstract

Optical tomography of the breast using a multi-channel time-resolved imager

Cited by 97 publications

References 23 publications

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

Detection and characterization of breast tumours by time-domain scanning optical mammography

Effects of the approximations of light propagation on quantitative photoacoustic tomography using two-dimensional photon diffusion equation and linearization

Contact Info

Product

Resources

About