Optical trapping of cord blood and adult blood -RBC

Hinge, Sarika; Banpurkar, Arun; Kulkarni, G. N.

doi:10.1117/12.2609509

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…Characterization of the trapping forces inside the optical manipulation mechanism can provide insights regarding the cellular-optical dynamics due to the trapping forces [372]. Another study demonstrates the duration of the post-optical tweezers exposure effect on RBC morphology and its membrane rigidness in adult blood [373] and umbilical cord blood [374]. Lastly, the aspects of single RBC ionization using laser-trapped techniques have also been considered, highlighting the potentials for measuring hemoglobin charges and other biophysical properties [375][376][377].…”

Section: Optical Trappingmentioning

confidence: 99%

Advances in Microfluidics for Single Red Blood Cell Analysis

et al. 2023

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The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. Researchers in this field have highlighted the vast potential in developing micro devices for industrial and academia usages, including lab-on-a-chip and organ-on-a-chip systems. This article critically reviews the current state-of-the-art and recent advances of microfluidics for single RBC analyses, including integrated sensors and microfluidic platforms for microscopic/tomographic/spectroscopic single RBC analyses, trapping arrays (including bifurcating channels), dielectrophoretic and agglutination/aggregation studies, as well as clinical implications covering cancer, sepsis, prenatal, and Sickle Cell diseases. Microfluidics based RBC microarrays, sorting/counting and trapping techniques (including acoustic, dielectrophoretic, hydrodynamic, magnetic, and optical techniques) are also reviewed. Lastly, organs on chips, multi-organ chips, and drug discovery involving single RBC are described. The limitations and drawbacks of each technology are addressed and future prospects are discussed.

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