Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies

Wang, Jiayu; Dong, Jianfei

doi:10.3390/s20143981

Cited by 47 publications

(31 citation statements)

References 144 publications

(243 reference statements)

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“…The fluorophore pyranine is a water-soluble dye that is used as a staining agent, pH indicator, and model system for excited-state proton transfer (ESPT) [36,37]. It is cell membrane impermeant and considered biocompatible [38]. When excited, pyranine gives off a characteristic yellow-green fluorescence.…”

Section: Resultsmentioning

confidence: 99%

Method for Passive Droplet Sorting after Photo-Tagging

et al. 2020

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We present a method to photo-tag individual microfluidic droplets for latter selection by passive sorting. The use of a specific surfactant leads to the interfacial tension to be very sensitive to droplet pH. The photoexcitation of droplets containing a photoacid, pyranine, leads to a decrease in droplet pH. The concurrent increase in droplet interfacial tension enables the passive selection of irradiated droplets. The technique is used to select individual droplets within a droplet array as illuminated droplets remain in the wells while other droplets are eluted by the flow of the external oil. This method was used to select droplets in an array containing cells at a specific stage of apoptosis. The technique is also adaptable to continuous-flow sorting. By passing confined droplets over a microfabricated trench positioned diagonally in relation to the direction of flow, photo-tagged droplets were directed toward a different chip exit based on their lateral movement. The technique can be performed on a conventional fluorescence microscope and uncouples the observation and selection of droplets, thus enabling the selection on a large variety of signals, or based on qualitative user-defined features.

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Section: Resultsmentioning

confidence: 99%

Method for Passive Droplet Sorting after Photo-Tagging

et al. 2020

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“…Implantable optical waveguides can, not only be implemented to assist the straightforward delivery of light inside the human body, but also to support more advanced tasks, including optogenetic stimulation [ 1 ], photodynamic therapy [ 2 ], cell imaging [ 3 ], and biological sensing [ 4 ]. The open literature already reports on the development of biodegradable optical fibers made from a plethora of different materials for potential biomedical applications [ 5 , 6 , 7 , 8 , 9 ]. In this review article, we focus on two main challenges involved when developing such waveguides: the fabrication process, and their eventual performance seen from an optical standpoint.…”

Section: Introductionmentioning

confidence: 99%

Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications

et al. 2021

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The limited penetration depth of visible light in biological tissues has encouraged researchers to develop novel implantable light-guiding devices. Optical fibers and waveguides that are made from biocompatible and biodegradable materials offer a straightforward but effective approach to overcome this issue. In the last decade, various optically transparent biomaterials, as well as different fabrication techniques, have been investigated for this purpose, and in view of obtaining fully fledged optical fibers. This article reviews the state-of-the-art in the development of biocompatible and biodegradable optical fibers. Whilst several reviews that focus on the chemical properties of the biomaterials from which these optical waveguides can be made have been published, a systematic review about the actual optical fibers made from these materials and the different fabrication processes is not available yet. This prompted us to investigate the essential properties of these biomaterials, in view of fabricating optical fibers, and in particular to look into the issues related to fabrication techniques, and also to discuss the challenges in the use and operation of these optical fibers. We close our review with a summary and an outline of the applications that may benefit from these novel optical waveguides.

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“…If vital signs, such as body temperature, vascular flow, and other metabolic factors, can be visualized at the surface of skins in real time with wearable sensors, this information would be helpful for establishing precise daily health care systems. [1] In industrial fields, visualization technologies for external stimuli are applicable to detection for damage to the products. [2] Therefore, many researchers have devoted much effort to develop luminochromic organic dyes with sensitive stimuli responsiveness.…”

Section: Introductionmentioning

confidence: 99%

Rational design for thermochromic luminescence in amorphous polystyrene films with bis‐o‐carborane‐substituted enhanced conjugated molecule having aggregation‐induced luminochromism

et al. 2021

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We designed the triad molecule, bis-o-carborane-substituted bis(thienylethynyl) benzene, as a filler for realizing thermochromic luminescent behaviors based on conventional polymer films, such as polystyrene. From the optical measurements, it was found that the triad can show solid-state emission and dual-luminescent properties with variable intensity ratios depending on media. From the mechanistic studies including the experiments with the methyl-substituted model compound, it was revealed that dual emission should be originated from the locally excited and twisted intramolecular charge transfer states, and the latter emission band is significantly enhanced in the solid states. We prepared amorphous films containing variable concentrations of the triad with the spin-coating method and investigated optical properties. It was found that intensity ratios were drastically changed by altering the concentration of the triad. By increasing the proportion of the triad, aggregation occurred, and emission color was apparently varied through the changes in intensity ratios of the dual emission property. Based on the aggregationinduced luminochromic property of the triad, thermochromic luminescence was finally realized by heating the amorphous films. The rational design for obtaining thermochromic luminescent amorphous films is illustrated in this paper.

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Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies

Cited by 47 publications

References 144 publications

Method for Passive Droplet Sorting after Photo-Tagging

Method for Passive Droplet Sorting after Photo-Tagging

Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications

Rational design for thermochromic luminescence in amorphous polystyrene films with bis‐o‐carborane‐substituted enhanced conjugated molecule having aggregation‐induced luminochromism

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