Optical weak measurement system with common path implementation for label-free biomolecule sensing

Abstract

A reflection-type phase-sensitive weak measurement for biosensing and chemical label-free sensing is presented. The phase difference between p and s polarizations in total internal reflection caused by biomolecular recognition is measured by weak value amplification. The system with p and s polarizations in a common path is stable and robust. The sensing process occurring on the silicon dioxide surface is achieved with a resolution of 3.6×10^-6 refractive index units. The applicability is demonstrated by real-time monitoring biomolecular interaction of IgG and protein A.

Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System

“…Therefore, the frequency domain weak measurement method has gradually become the focus. The frequency-domain weak measurement method has also been applied to a variety of biological chemistry sensors, such as the combination of weak measurements and Mach–Zehnder interferometers to measure blood glucose concentrations in mice [ 16 ], and combination of weak measurement techniques and total internal reflection (TIR) sensors to realize interaction with biomacromolecules [ 17 ] and a molecularly-imprinted polymer (MIP) sensor based on weak measurement technology [ 18 ]. These applications not only realize the real time application of molecular concentration change or mutual reaction, but also greatly improve the sensitivity of these sensors [ 19 ].…”

High-Throughput Chiral Molecule Determination Based on Multi-Channel Weak Measurement

“…Accordin g to [8] and [29], when point state of P is measured, it would only be associate with the imaginary part of weak value. Therefore, the shift of center wavelength   100 / lC  = (12) In this equation, the optical activity [α] and concentration C was the inherent feature of liquid sample composed of chiral molecule, and l presents the interaction length of the light and the sample. Depending on the expression of Eq.…”

“…In 2014, Salazar-Serrano et al [11] demonstrated that the weak measurement systems could be realized in any wave-based interference systems, which offers indispensable theoretical basis for applications of the weak measurement system. In 2016, Zhang et al [12] introduced the weak measurement into the field of biomedicine with a universal system for the first time and achieved the monitoring of chiral molecules based on the optical weak measurement. In 2018, Li et al [13] introduced the chiral sensor based on weak value amplification for the determination of Proline enantiomers.…”

A Differential Detection Method Based on a Linear Weak Measurement System

“…The implementation of weak measurement in the frequency domain makes the weak measurement technology widely developed in the field of biomolecule detection. Our previous work has demonstrated that phase changes in the optical system induced by analytes or biochemical reactions in frequency domain weak measurements can cause a shift in the center wavelength of the output spectrum [14][15][16][17][18][19]. In addition, the combination of frequency domain weak measurement techniques and total internal reflection techniques provides significant advantages in phase sensitive biotransmissions on a single glass surface with a common path.…”