Optical Whispering-Gallery-Mode Microbubble Sensors

Zhao, Xuyang; Guo, Zhihe; Zhou, Yi; Guo, Junhong; Liu, Zhiran; Li, Yuxiang; Luo, Man; Wu, Xiang

doi:10.3390/mi13040592

Cited by 34 publications

(7 citation statements)

References 131 publications

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“…The capillary wall thickness can eventually be further thinned using hydrofluoric acid (HF) injected within its structure. This step is usually performed by withdrawing a solution at a constant flow rate using a microperistaltic pump or syringe pusher. − …”

Section: Generalities On Wgm Sensorsmentioning

confidence: 99%

From Whispering Gallery Mode Resonators to Biochemical Sensors

et al. 2023

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Optical biosensors are frontrunners for the rapid and real-time detection of analytes, particularly for low concentrations. Among them, whispering gallery mode (WGM) resonators have recently attracted a growing focus due to their robust optomechanical features and high sensitivity, measuring down to single binding events in small volumes. In this review, we provide a broad overview of WGM sensors along with critical advice and additional “tips and tricks” to make them more accessible to both biochemical and optical communities. Their structures, fabrication methods, materials, and surface functionalization chemistries are discussed. We propose this reflection under a pedagogical approach to describe and explain these biochemical sensors with a particular focus on the most recent achievements in the field. In addition to highlighting the advantages of WGM sensors, we also discuss and suggest strategies to overcome their current limitations, leaving room for further development as practical tools in various applications. We aim to provide new insights and combine different knowledge and perspectives to advance the development of the next generation of WGM biosensors. With their unique advantages and compatibility with different sensing modalities, these biosensors have the potential to become major game changers for biomedical and environmental monitoring, among many other relevant target applications.

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Section: Generalities On Wgm Sensorsmentioning

confidence: 99%

From Whispering Gallery Mode Resonators to Biochemical Sensors

et al. 2023

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“…In order to improve the anti-interference ability of the sensor and reduce the system noise, the microbubble and the fiber taper are wrapped with MY-133-V2000 to form a packaged sample. The fabrication processes of the packaged microbubble resonator are similar to Refs [17,27] and the schematic diagram of the sensor is shown in Figure 1A. First, fix the fiber taper on the glass scaffold with UV glue.…”

Section: Fabrication Processes and Experimental Setupmentioning

confidence: 99%

“…Whispering gallery mode (WGM) microcavity resonator has been exploited for a broad field of fundamental research and practical applications in recent years benefits by their high quality (Q) factor and small mode volume, which can be used as one of the label-free biosensors [14][15][16][17]. The detection limits (DLs) of some WGM biosensors such as microtoroid and microbubble have reached to several aM or even to single-molecule level [18,19].…”

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confidence: 99%

Label‐free detection of cardiac troponin‐I with packaged thin‐walled microbubble resonators

Guo

Zhao

Zhou

et al. 2022

Journal of Biophotonics

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The measurement of cardiac troponin‐I (cTnI) is widely used for diagnosing acute myocardial infarction (AMI) diseases because of its myocardial specificity. Packaged microbubble resonators with thin wall are utilized for label‐free and specific detection of cTnI based on whispering gallery mode (WGM). This packaged structure can provide a good protection for the biosensor, improve the anti‐interference ability of the sensor and reduce the system noise. The theoretical detection limit of the biosensors for cTnI in phosphate buffer saline (PBS) is 0.4 ag mL−1 (0.02 aM). Furthermore, we demonstrated that the biosensors can be used to detect cTnI molecules in simulated serum and the theoretical detection limit is also 0.4 ag mL−1 (0.02 aM). These results are much far below the clinical cut‐off value and show a huge application potential for the detection of cardiac biomarkers of AMI.

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“…Optical microcavities with high quality factor ( Q ) have extremely narrow resonance line widths, which correspond to higher resolution. − Therefore, optical microcavities have been widely studied for high-precision sensing of physical quantities, such as acoustic, , magnetic, , force, , and displacement sensing . Over the past decade, high-precision acceleration sensing research has also gradually exploited optical microcavities.…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh Resolution Acceleration Sensing Based on Prism-Microcavity Dissipative Coupling Architecture

Jia,

Rong,

et al. 2024

ACS Photonics

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Optical microcavities with ultrahigh quality factors are still currently considered as one of the solutions to achieve miniaturized and ultrahigh precision accelerometers, but the measurement of sub-ng/Hz 1/2 acceleration has yet to be proven. Here we propose a new architecture for optomechanical acceleration sensing using prism and microcavity coupling. The relative displacement between the coupled prism and the microcavity is read in real time using the carrier information on the resonance spectrum, which inverts the loaded acceleration signal. In the sensing framework of the dissipative coupling mechanism, the self-referencing detection approach immunizes the majority of the common mode noise. The resonance frequency shift induced by the mismatch of the optical modes within the evanescent field improves the acceleration resolution to 91 pg/Hz 1/2 at 40 Hz, which to the best of our knowledge is the first reported measurement of sub-ng/Hz 1/2 acceleration based on a microcavity sensing architecture. It is expected to find applications in industrial manufacturing, inertial navigation, and gravity measurements.

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Optical Whispering-Gallery-Mode Microbubble Sensors

Cited by 34 publications

References 131 publications

From Whispering Gallery Mode Resonators to Biochemical Sensors

From Whispering Gallery Mode Resonators to Biochemical Sensors

Label‐free detection of cardiac troponin‐I with packaged thin‐walled microbubble resonators

Ultrahigh Resolution Acceleration Sensing Based on Prism-Microcavity Dissipative Coupling Architecture

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