Optimal bovine collagen concentration to achieve tracheal epithelial coverage of collagen sponges

Suzuki, Ryo; Nakamura, Ryosuke; Nakaegawa, Yuta; Nomoto, Yukio; Fujimoto, Ichiro; Semura, Kayoko; Hazama, Akihiro; Omori, Koichi

doi:10.1002/lary.25989

Cited by 9 publications

(7 citation statements)

References 30 publications

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“…Some biomaterials of collagen-based scaffolds are obtained directly by lyophilizing pure collagen or blends of collagen–polysaccharide [ 9 , 12–14 ]. As this kind of scaffold preparation approach does not undergo collagen fibril reconstruction in vitro , these scaffolds substantially lack the structure of native fibrils, which is a crucial tension element existing in natural ECM.…”

Section: Introductionmentioning

confidence: 99%

Construction and evaluation of fibrillar composite hydrogel of collagen/konjac glucomannan for potential biomedical applications

Tang

Chen

Guo

et al. 2018

Regenerative Biomaterials

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Konjac glucomannan (KGM) is recognized as a safe material for its health-promoting benefits and thus widely used in various fields including pharmaceutical industry. In recent decades, the combination of collagen and KGM attracts more attentions for biomedical purpose, especially the hybrid films of collagen–KGM or collagen–KGM–polysaccharide. In this study, to further and deeply develop the intrinsic values of both collagen and KGM as biomaterials, a novel kind of composite hydrogel comprising collagen and KGM at a certain ratio was fabricated under mild conditions via fibrillogenesis process of the aqueous blends of collagen and KGM that experienced deacetylation simultaneously. The chemical composition, microcosmic architectures, swelling behavior, biodegradation and dynamic mechanic properties of such resulted composite hydrogels were systematically investigated. Biologic experiments, including cell culture in vitro and hypodermic implantation in vivo, were also conducted on these collagen/KGM composite hydrogels to evaluate their biologic performances. The relevant results prove that, based on collagen self-assembly behavior, this synthesis strategy is efficient to construct a composite hydrogel of collagen/KGM with improved mechanical properties, biodegradability, excellent biocompatibility and bioactivity, which are promising for potential biomedical applications such as tissue engineering and regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

Construction and evaluation of fibrillar composite hydrogel of collagen/konjac glucomannan for potential biomedical applications

Tang

Chen

Guo

et al. 2018

Regenerative Biomaterials

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“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate laryngeal tissue engineering 85‐87,91,92,94,96,97,198‐306 …”

Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA.

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“…Many bio-materials have been developed based on collagens from other species, for example, bovine collagen, sea urchin, horse serum and deer antler collagen [13][14][15][16][17]. To replace human collagen material and to commercialize an easily obtainable product, many researchers have performed experimental and clinical tests on many materials to achieve the appropriate properties.…”

Section: Discussionmentioning

confidence: 99%

Application of a Collagen Patch Derived from Duck Feet in Acute Tympanic Membrane Perforation

Kim

Jeong

Park

et al. 2017

Tissue Eng Regen Med

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We investigated the utility of the duck-feet collagen extraction patching procedure in the traumatic tympanic membrane (TM) perforation via a comparison with spontaneous healing or paper patch. Fifty-six ears of adult male Sprague-Dawley rats, each weighing in the range of 250 to 300 g, were used for the animal studies. Sixteen rats had oneside ear in the control group and the opposite-side ear in the treated groups. The remaining twelve rats had a one-side ear with the duck-feet collagen patch and the opposite-side ear with a paper patch. The proliferating cell nuclear antigen (PCNA) expression cells were calculated among the 200 basal cells, and the expression percentage was identified as the labeling index. The healing of the perforation in the duck-feet collagen patch group was confirmed to be more rapid compared to the healing of the other groups. PCNA staining was observed in the migrating portion of PCNA enhanced cell to collagen scaffold in Post operative day (POD) 7 of collagen patch group. Thus, the adhesive effect of the duck-feet collagen patch to perforated margin was better than that of the paper patch. After completing the healing process, the collagen patch shrank and detached from the tympanic membrane (POD 14). In this study, we confirmed that the use of a duck-feet collagen patch had the advantage of early healing, inducing natural TM contour, and disappearing ability after the patch effect is complete.

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Optimal bovine collagen concentration to achieve tracheal epithelial coverage of collagen sponges

Abstract: NA Laryngoscope, 126:E396-E403, 2016.

Cited by 9 publications

References 30 publications

Construction and evaluation of fibrillar composite hydrogel of collagen/konjac glucomannan for potential biomedical applications

Construction and evaluation of fibrillar composite hydrogel of collagen/konjac glucomannan for potential biomedical applications

Tissue engineering applications in otolaryngology—The state of translation

Application of a Collagen Patch Derived from Duck Feet in Acute Tympanic Membrane Perforation

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