At present, due to the serious environmental pollution in China, the planning of multi-energy system is becoming more and more urgent. To meet people's demand for energy planning of a multi-energy system, this paper proposes a method of source-network storage-load coordination of the multi-energy system based on regional planning. By taking the planning cost as the objective function, a three-level multi-energy systems collaborative planning model is constructed to achieve the optimal planning and allocation of energy. Taking the conventional multi-energy system source-network load storage coordination method as the contrast object, the feasibility of the proposed method is proved by the comparative experiment. The experimental results show that the proposed method can effectively reduce the frequency fluctuation caused by the uncertainty of the source load, and effectively control the frequency fluctuation, which has a positive significance for improving energy efficiency.