2022
DOI: 10.1016/j.idm.2021.11.006
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Optimal control analysis of hepatocytic-erythrocytic dynamics of Plasmodium falciparum malaria

Abstract: This paper presents an in-host malaria model subject to anti-malarial drug treatment and malaria vaccine antigens combinations. Pontryagin's Maximum Principle is applied to establish optimal control strategies against infected erythrocytes, infected hepatocytes and malaria parasites. Results from numerical simulation reveal that a combination of pre-erythrocytic vaccine antigen, blood schizontocide and gametocytocide drugs would offer the best strategy to eradicate clinical P. falciparum … Show more

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