Optimal control analysis of vector-host model with saturated treatment

Abstract

Vector-host infectious diseases remain a challenging issue and cause millions of deaths each year globally. In such outbreaks, many countries especially developing or underdevelopment faces a situation where the number of infected individuals is getting larger and the medical facilities are limited. In this paper, we construct an epidemic model to explore the transmission dynamics of vector-borne diseases with nonlinear saturated incidence rate and saturated treatment function. This type of incidence rate, as well as the saturated treatment function, is also known as the Holling type II form and describes the effect of delayed treatment. Initially, we formulate a mathematical model and then present the basic analysis of the model including the positivity and boundedness of the solution. The threshold quantity R 0 is presented and the stability analysis of the system is carried out for the model equilibria. The global stability results are shown using the Lyapunov function of Goh-Voltera type. The existence of backward bifurcation is discussed using the central manifold theory. Further, the global sensitivity analysis of the model is carried out using the Latin Hypercube sampling and the partial rank correlation coefficient techniques. Moreover, an optimal control problem is formulated and the necessary optimality conditions are investigated in order to eradicate the disease in a community. Four strategies are presented by choosing different set of controls combination for the disease minimization. Finally, the numerical simulations of each strategy are depicted to demonstrate the importance of suggesting control interventions on the disease dynamics and eradication.

Optimal control analysis of COVID-19 vaccine epidemic model: a case study

“…The constants for are used for the balancing cost factors, and represents the final time. Due to nonlinear intervention among the population, quadratic objective functional is take into account, for details see references [ 7 , 8 , 15 , 16 ].…”

“…Due to nonlinear intervention among the population, quadratic objective functional is take into account, for details see references [7,8,15,16].…”

“…The authors carried out stability analysis and provide numerical simulation in order to predict the future forecast. Ullah et al [ 7 , 8 ] formulated new epidemic models coupled with optimal control problems to study the importance of some specific variable control interventions on the pandemic of COVID-19 in Pakistan and vector-host diseases. The purpose of the study was to explore the transmission pattern as well as to set up possible control strategies to reduce the infection spreading.…”

On the Effects of Saturation Terms on A SEIR Epidemic Model with Infected and Susceptible Compartments

“…Their study showed that the best possible strategy that can minimize the number of infected humans is the application of their speculated control methods simultaneously. Advancing the research work in [10], an optimal control analysis of a vector-host model with saturated treatment was studied in [11]. Their research suggested different control intervention strategies useful during disease eradication.…”