2019
DOI: 10.19139/soic.v7i3.836
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Optimal Control and Sensitivity Analysis of a Fractional Order TB Model

Abstract: A Caputo fractional-order mathematical model for the transmission dynamics of tuberculosis (TB) was recently proposed in [Math. Model. Nat. Phenom. 13 (2018), no. 1, Art. 9]. Here, a sensitivity analysis of that model is done, showing the importance of accuracy of parameter values. A fractional optimal control (FOC) problem is then formulated and solved, with the rate of treatment as the control variable. Finally, a cost-effectiveness analysis is performed to assess the cost and the effectiveness of the contro… Show more

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Cited by 20 publications
(25 citation statements)
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“…When α = 1, the conditions (9) and (12) are verified, and we retrieve from our Theorem 1 the results established in [17,18] about the exponential stability of system (8) on Ω, which is equivalent to +∞ 0 S(t)z 2 dt < ∞, ∀z ∈ L 2 (Ω). In our next theorem, we provide sufficient conditions that guaranty the strong stability of the fractional order differential system (8). The result generalizes the asymptotic result established by Matignon for finite dimensional state spaces, where the dynamics of the system A is considered to be a matrix with constant coefficients in R n [23].…”
Section: Stability Of Time Fractional Differential Systemsmentioning
confidence: 78%
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“…When α = 1, the conditions (9) and (12) are verified, and we retrieve from our Theorem 1 the results established in [17,18] about the exponential stability of system (8) on Ω, which is equivalent to +∞ 0 S(t)z 2 dt < ∞, ∀z ∈ L 2 (Ω). In our next theorem, we provide sufficient conditions that guaranty the strong stability of the fractional order differential system (8). The result generalizes the asymptotic result established by Matignon for finite dimensional state spaces, where the dynamics of the system A is considered to be a matrix with constant coefficients in R n [23].…”
Section: Stability Of Time Fractional Differential Systemsmentioning
confidence: 78%
“…The next theorem provides necessary and sufficient conditions for exponential stability of the abstract fractional order differential system (8).…”
Section: Stability Of Time Fractional Differential Systemsmentioning
confidence: 99%
“…, u n ] T , such that the elements of A and U are unknown. By utilizing (5), (9), (13), and the initial conditions given in (3), for s = 1, 2, . .…”
Section: Numerical Solution Of Problem (1)-(3)mentioning
confidence: 99%
“…where u n (t) has been given in (14). For obtaining an error estimate for the state function x(·), we suppose that D α x(·) ∈ C 3 [0, t f ] and is approximated using (13). Also, suppose that D T Ψ(t)…”
Section: Error Estimatementioning
confidence: 99%
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