Aiming at the objective uncertainty, subjective uncertainty, and extreme events may be in a dynamic system simultaneously. This paper focuses on the differential game problem of a linear quadratic jump uncertain stochastic system. The system is described by both a jump uncertain differential equation and a stochastic differential equation. The principle of optimality and equation of optimality are established. Then, a differential game model based on linear quadratic jump uncertain stochastic system is constructed. Furthermore, Nash equilibrium are discussed by using the obtained equation. Finally, its application in the dynamic investment decision of enterprises is given, and numerical simulations are performed. This approach offers a new method for quantitative analysis in future studies.