PurposeThis paper aims to explore the potential of blockchain technology (BT) to support the operational excellence in perishable food supply chain (PFSC) during outbreaks, by doing use-case analysis.Design/methodology/approachA systematic literature review is performed to determine the dimensions of operational excellence in the food supply chain (FSC), then a single use-case analysis is conducted to explore the potential of blockchain in order to achieve operational excellence for PFSC during the pandemics by applying context, interventions, mechanism and outcomes (CIMO) logic.FindingsThe findings of this study reveal that blockchain capabilities such as immutability and transparency, visibility, traceability, integration and interoperability, disintermediation and decentralisation, smart contracts and consensus mechanism provide better sustainable operational excellence outcomes for PFSCs to be more responsive, flexible, efficient and collaborative to cope with the impacts of COVID-19.Research limitations/implicationsThis research employs only one real case with multiple PFSC participants. Statistical generalisation is not possible at this stage of the research. However, the findings are not restricted to this single use-case.Practical implicationsThis study provides a research direction to explore the potential of BT to achieve operational excellence in the PFSC during outbreaks and generates prescriptive knowledge for better managerial decision-making across the PFSC during outbreaks.Originality/valueThis research conducts semi-structured interviews with different participants in one blockchain ecosystem to understand multiple participants' perspectives of operational excellence within PFSC.