Low frequency oscillation has been a major threat in large interconnected power system. These low frequency oscillations curtain the power transfer capability of the line. Power system stabilizer (PSS) helps in diminishing these low frequency oscillations by providing auxiliary control signal to the generator excitation input, thereby restoring stability of the system. In this chapter, the authors have incorporated the concept of oppositional based learning (OBL) along with differential search algorithm (DSA) to solve PSS problem. The proposed technique has been implemented on both single input and dual input PSS, and comparative study has been done to show the supremacy of the proposed techniques. The convergence characteristics as well authenticate the sovereignty of the considered algorithms.