2003
DOI: 10.1205/026387603322482130
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Optimal Design of Solution Crystallization Processes with Rigorous Models

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Cited by 31 publications
(32 citation statements)
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“…The use of both of these functionalities has been documented in the literature for industrial processes [168,169]. Both functions have also been used extensively in the simulation and optimization of batch crystallization processes for pharmaceutical applications [170][171][172]. While a large number of models are available in the gPROMS™ model libraries, the connection of these models and their integration into processes that will run without error is not always straightforward.…”
Section: Gproms™ Gproms™ Is a Modeling Platform Developed By Process mentioning
confidence: 99%
“…The use of both of these functionalities has been documented in the literature for industrial processes [168,169]. Both functions have also been used extensively in the simulation and optimization of batch crystallization processes for pharmaceutical applications [170][171][172]. While a large number of models are available in the gPROMS™ model libraries, the connection of these models and their integration into processes that will run without error is not always straightforward.…”
Section: Gproms™ Gproms™ Is a Modeling Platform Developed By Process mentioning
confidence: 99%
“…The purpose of this paper is to show that valuable product quality information can be obtained by combining molecular simulations and process modeling. Information on the development of accurate crystallization process models can be found elsewhere [5]. It was therefore decided to work with a relatively simple process model which assumes negligible hydrodynamic effects, agglomeration, attrition, and polymorph transitions.…”
Section: Process Simulations Of Polymorph Crystallizationmentioning
confidence: 99%
“…There are therefore two population balances, n 1 and n 2 , for the two polymorphs 1 and 2, which develop depending on the time dependent supersaturation. The time evolution of the crystal size distributions is described with population balances coupled with the component mass balances and the enthalpy balance [5]. Assuming a well mixed vessel, the population balance for a batch anti-solvent crystallization process is given by:…”
Section: Process Simulations Of Polymorph Crystallizationmentioning
confidence: 99%
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“…18 There has been much recent interest in coupling the solution of PBEs with computational fluid dynamics to assess the effects of nonideal mixing on the particle size distribution. 17,[19][20][21][22] This involves solving a spatially varying PBE, which typically has four or more coordinates (three spatial coordinates and one or more internal coordinates). Typically such simulations require on the order of a day.…”
Section: Introductionmentioning
confidence: 99%