Optimal Diet Strategies for Weight Loss and Weight Loss Maintenance

Kim, Ju Young

doi:10.7570/jomes20065

Cited by 107 publications

(87 citation statements)

References 92 publications

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“…Nevertheless, reducing total caloric intake enough to lose weight requires tremendous effort, and maintaining it over the long term is much more challenging. Alternatively, carbohydrate-restricted diets and intermittent fasting (IF) are emerging as relatively easy and effective popular dietary regimens for reducing body weight [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management: consensus statement of the Korean Society for the Study of obesity, Korean Diabetes Association, and Korean Society of Hypertension

Choi

Cho²,

Kim³

et al. 2022

Clin Hypertens

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Background Carbohydrate-restricted diets and intermittent fasting (IF) have been rapidly gaining interest among the general population and patients with cardiometabolic disease, such as overweight or obesity, diabetes, and hypertension. However, there are limited expert recommendations for these dietary regimens. This study aimed to evaluate the level of scientific evidence on the benefits and harms of carbohydrate-restricted diets and IF to make responsible recommendations. Methods A meta-analysis and systematic literature review of 66 articles on 50 randomized controlled clinical trials (RCTs) of carbohydrate-restricted diets and ten articles on eight RCTs of IF was performed. Results Based on the analysis, the following recommendations are suggested. In adults with overweight or obesity, a moderately-low carbohydrate or low carbohydrate diet (mLCD) can be considered as a dietary regimen for weight reduction. In adults with type 2 diabetes, mLCD can be considered as a dietary regimen for improving glycemic control and reducing body weight. In contrast, a very-low carbohydrate diet (VLCD) and IF are recommended against in patients with diabetes. Furthermore, no recommendations are suggested for VLCD and IF in adults with overweight or obesity, and carbohydrate-restricted diets and IF in patients with hypertension. Conclusion Here, we describe the results of our analysis and the evidence for these recommendations.

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Section: Introductionmentioning

confidence: 99%

Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management: consensus statement of the Korean Society for the Study of obesity, Korean Diabetes Association, and Korean Society of Hypertension

Choi

Cho²,

Kim³

et al. 2022

Clin Hypertens

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show abstract

“…As a key macronutrient and a source of energy, dietary protein plays significant roles in maintaining health. For many years, protein-rich diets have been recommended due to their satiety-inducing and muscle-building effects [ 79 , 80 , 81 , 82 , 83 ]. It was proposed for tumor patients to follow a high protein diet to maintain health during therapy [ 84 ].…”

Section: Diet and Response To Icismentioning

confidence: 99%

Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors

Zhang

et al. 2022

Life

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Immunotherapy has revolutionized the established therapeutics against tumors. As the major immunotherapy approach, immune checkpoint inhibitors (ICIs) achieved remarkable success in the treatment of malignancies. However, the clinical gains are far from universal and durable, because of the primary and secondary resistance of tumors to the therapy, or side effects induced by ICIs. There is an urgent need to find safe combinatorial strategies that enhance the response of ICIs for tumor treatment. Diets have an excellent safety profile and have been shown to play pleiotropic roles in tumor prevention, growth, invasion, and metastasis. Accumulating evidence suggests that dietary regimens bolster not only the tolerability but also the efficacy of tumor immunotherapy. In this review, we discussed the mechanisms by which tumor cells evade immune surveillance, focusing on describing the intrinsic and extrinsic mechanisms of resistance to ICIs. We also summarized the impacts of different diets and/or nutrients on the response to ICIs therapy. Combinatory treatments of ICIs therapy with optimized diet regimens own great potential to enhance the efficacy and durable response of ICIs against tumors, which should be routinely considered in clinical settings.

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“…• Other Fasting/CR-mimicking dietary interventions comprise various experimental avenues that aim at eliciting (some) CR-like molecular and physiological effects, such as the fasting-mimicking diet (FMD; Brandhorst et al, 2015;Choi et al, 2016a;Wei et al, 2017), ketogenic diets (Ludwig, 2020), or low-carbohydrate/fat diets (Kim, 2021).…”

Section: Metabolic Switchmentioning

confidence: 99%

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

et al. 2021

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Age-associated diseases are rising to pandemic proportions, exposing the need for efficient and low-cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and physiological levels. While nutrition and health are closely intertwined, our limited understanding of how diet precisely influences disease often precludes the medical use of specific dietary interventions. Caloric restriction (CR) has approached clinical application as a powerful, yet simple, dietary modulation that extends both life-and healthspan in model organisms and ameliorates various diseases. However, due to psychological and social-behavioral limitations, CR may be challenging to implement into real life. Thus, CRmimicking interventions have been developed, including intermittent fasting, time-restricted eating, and macronutrient modulation. Nonetheless, possible side effects of CR and alternatives thereof must be carefully considered. We summarize key concepts and differences in these dietary interventions in humans, discuss their molecular effects, and shed light on advantages and disadvantages.

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Optimal Diet Strategies for Weight Loss and Weight Loss Maintenance

Abstract: This is a PDF file of an article accepted, but it is not yet the definitive version of record.

Cited by 107 publications

References 92 publications

Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management: consensus statement of the Korean Society for the Study of obesity, Korean Diabetes Association, and Korean Society of Hypertension

Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management: consensus statement of the Korean Society for the Study of obesity, Korean Diabetes Association, and Korean Society of Hypertension

Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

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