Optimal doses of sevoflurane and propofol in rabbits

Terada, Yoshihide; Ishiyama, Tadahiko; Asano, Nobumasa; Kotoda, Masakazu; Ikemoto, Kodai; Shintani, Noriyuki; Sessler, Daniel I.; Matsukawa, Takashi

doi:10.1186/1756-0500-7-820

Cited by 11 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding sevoflurane and DEX infusion in the present study, 5% sevoflurane was given to maintain the end-tidal sevoflurane at a maximum of 3.9%. 18,19 The 5% sevoflurane used in the present study was 2 to 3 times the minimum alveolar concentration of humans as is common for rabbits. For this reason, we set the infusion dose of DEX at 3 times that in humans.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dexmedetomidine on Oral Mucosal Blood Flow and the Absorption of Lidocaine

Tomita

Yamazaki

Togami

et al. 2018

Anesthesia Progress

View full text Add to dashboard Cite

Dexmedetomidine (DEX) is a sedative and analgesic agent that acts via the alpha-2 adrenoreceptor and is associated with reduced anesthetic requirements, as well as attenuated blood pressure and heart rate in response to stressful events. A previous study reported that cat gingival blood flow was controlled via sympathetic alpha-adrenergic fibers involved in vasoconstriction. In the present study, experiment 1 focused on the relationship between the effects of DEX on alpha adrenoreceptors and vasoconstriction in the tissues of the oral cavity and compared the palatal mucosal blood flow (PMBF) in rabbits between general anesthesia with sevoflurane and sedation with DEX. We found that the PMBF was decreased by DEX presumably because of the vasoconstriction of oral mucosal vessels following alpha-2 adrenoreceptor stimulation by DEX. To assess if this vasoconstriction would allow decreased use of locally administered epinephrine during DEX infusion, experiment 2 in the present study monitored the serum lidocaine concentration in rabbits to compare the absorption of lidocaine without epinephrine during general anesthesia with sevoflurane and sedation with DEX. The depression of PMBF by DEX did not affect the absorption of lidocaine. We hypothesize that this is because lidocaine dilates the blood vessels, counteracting the effects of DEX. In conclusion, despite decreased palatal blood flow with DEX infusion, local anesthetics with vasoconstrictors should be used in implant and oral surgery even with administered DEX.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Dexmedetomidine on Oral Mucosal Blood Flow and the Absorption of Lidocaine

Tomita

Yamazaki

Togami

et al. 2018

Anesthesia Progress

View full text Add to dashboard Cite

show abstract

“…One recent study demonstrated that rabbits require sevolurane ET concentrations of 3.9±0.2 to maintain unconsciousness in the absence of nociceptive stimulation. 11 The delivery of sevolurane and isolurane in the rabbits of the current investigation was titrated to efect at the discretion of the anaesthetist in charge, based on the results of the clinical monitoring of each patient. This resulted in sevolurane end-tidal concentrations that were slightly lower than those reported by Terada and colleagues, a inding that can be explained by the concomitant use of other anaesthetic and analgesic drugs that presumably decreased the minimum alveolar concentration of sevolurane.…”

Section: Discussionmentioning

confidence: 99%

“…One recent study demonstrated that rabbits require sevoflurane ET concentrations of 3.9±0.2 to maintain unconsciousness in the absence of nociceptive stimulation 11 . The delivery of sevoflurane and isoflurane in the rabbits of the current investigation was titrated to effect at the discretion of the anaesthetist in charge, based on the results of the clinical monitoring of each patient.…”

Section: Discussionmentioning

confidence: 99%

Use of atracurium and its reversal with neostigmine in 14 pet rabbits undergoing ophthalmic surgery: a retrospective study

Adami

Sanchez²,

Monticelli

2019

Veterinary Record

View full text Add to dashboard Cite

The objective of this retrospective study was to report the clinical use of atracurium and its reversal with neostigmine in pet rabbits. The medical records of 14 rabbits undergoing anaesthesia for ophthalmic surgery were located through a search of the hospital’s database. Demographic data and data pertaining to the use of the neuromuscular blocker and its reversal were analysed. After intravenous administration of 0.44±0.4 mg/kg atracurium (total dose), 11 rabbits experienced at least one of the following cardiovascular responses: hypotension, defined as systolic arterial pressure less than 75 mmHg (n=6), hypotension with decreased heart rate (HR) (n=1), hypotension with increased HR (n=1), decreased arterial blood pressure (ABP) without hypotension (n=6), decreased ABP with decreased HR (n=1), or increased HR (n=2, ABP reading could not be taken). Two of these 11 rabbits also experienced severe intraoperative hypothermia. The neuromuscular block was monitored with a train-of-four nerve-stimulation pattern, and reversed, with intramuscular 0.01–0.045 mg/kg neostigmine and 0.01–0.02 mg/kg glycopyrronium, after the return of at least two out of four muscular twitches following nerve stimulation. Decrease in ABP and possibly hypothermia are likely intraoperative complications when clinical doses of atracurium are administered to pet rabbits. Measures should be taken to detect their occurrence in order to treat them promptly.

show abstract

“…Our preliminary experiment and our previous study [ 11 ] showed that JM-1232(-) decreases BIS values. BIS is commonly used to measure hypnotic effect, and appears reliable in rabbits [ 12 ]. It therefore seems likely that JM-1232(-) decreased neural activity and CMR.…”

Section: Discussionmentioning

confidence: 99%

The effects of topical and intravenous JM-1232(-) on cerebral pial microvessels of rabbits

et al. 2015

Self Cite

View full text Add to dashboard Cite

BackgroundJM-1232(-) is a novel anesthetic agent which acts through gamma-aminobutyric acid receptors. Cerebral pial vascular effects of JM-1232(-) are unknown. We thus evaluated topical and intravenous effects of JM-1232(-) on cerebral pial microvessels in rabbits, and the extent to which carbon dioxide (CO2) reactivity is preserved.MethodsClosed cranial windows were used to visualize cerebral pial circulation in 29 Japanese white rabbits. In the first experiment, the cranial window was superfused with increasing concentrations of JM-1232(-): 10-11, 10-9, 10-7, 10-5 mol/L, n = 8 per concentration. In the second experiment, we examined the effects of an intravenous bolus of 1 mg/kg bolus of JM-1232(-), followed by the continuous infusion at 0.3 mg/kg/minute on cerebral pial vascular alteration (n = 9). In the third, we examined CO2 reactivity of cerebral pial vessels under JM-1232(-) (n = 6) or sevoflurane anesthesia (n = 6).ResultsTopical application of JM-1232(-) did not change pial venular diameter, and constricted arterials only at the highest concentration. Intravenous administration of JM-1232(-) produced cerebral pial constriction which gradually diminished over time. Under intravenous administration of JM-1232(-) and inhaled sevoflurane, diameters of vessels increased in parallel with CO2 partial pressure. Slopes of linear regression and correlation coefficients in arterioles and venules were comparable for JM-1232(-) anesthesia and sevoflurane anesthesia.ConclusionsTopical application of JM-1232(-) had little effect on cerebral pial vessels. Intravenous administration produced vasoconstriction of cerebral pial arterioles and venules, however those changes were clinically unimportant. In addition, JM-1232(-) did not impair CO2 responsiveness. At least from the perspective of vascular reactivity, JM-1232(-) thus appears safe for neurosurgical patients.

show abstract

Optimal doses of sevoflurane and propofol in rabbits

Cited by 11 publications

References 36 publications

The Effect of Dexmedetomidine on Oral Mucosal Blood Flow and the Absorption of Lidocaine

The Effect of Dexmedetomidine on Oral Mucosal Blood Flow and the Absorption of Lidocaine

Use of atracurium and its reversal with neostigmine in 14 pet rabbits undergoing ophthalmic surgery: a retrospective study

The effects of topical and intravenous JM-1232(-) on cerebral pial microvessels of rabbits

Contact Info

Product

Resources

About