Optimal economic productivity of exopolysaccharides from lactic acid bacteria with production possibility curves

Lin, Ta‐Chen; Chen, Chun-Yeh; Bang-yuan, Chen; Shaw, Jei‐Fu; Chen, Yuh‐Shuen

doi:10.1002/fsn3.1079

Cited by 10 publications

(6 citation statements)

References 33 publications

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“…Exopolysaccharides from LAB have attained substantial attention in the past decade due to their capability to inhibit bacterial toxins produced by Bacillus cereus [ 213 ]. The production of Lactobacillus EPS is regulated by the culture conditions and nutrient compositions during fermentation [ 214 , 215 ]. For instance, the production of L. rhamnosus EPS was significantly increased by 40 to 50% following 48 h of co-fermentation with S. cerevisiae , owing to the upregulation of EPS operons expression that enhanced amino acid biosynthesis, carbohydrate metabolism, and fatty acid metabolisms [ 216 ].…”

Section: Bacterial Polysaccharidesmentioning

confidence: 99%

“…One such challenge would be the cost required for their production. As their extraction is often hindered by low yields, optimisation of growth medium composition and extraction methods are essential [ 210 , 215 , 254 ]. In addition, other factors such as type of carbon sources and pH also significantly influence EPS structure and yields [ 255 ].…”

Section: Challenges Of Lactobacillus Sams Applicatmentioning

confidence: 99%

“…The utilisation of low-cost agricultural waste-based media potentially reduce the high cost inputs during large-scale fermentation process and meet the high market demand of lactobacilli SAMs in the future. Moreover, the cost of lactobacilli SAMs production can be reduced by determining the most economical culture medium composition for the maximum yield [ 215 ]. For instance, economic modelling via formula adjustment and production possibility curve (PPC) were performed to assess the carbon source for optimal culture medium composition and optimal productivity set (OPS) of L. acidophilus EPS production [ 215 ].…”

Section: Challenges Of Lactobacillus Sams Applicatmentioning

confidence: 99%

“…Moreover, the cost of lactobacilli SAMs production can be reduced by determining the most economical culture medium composition for the maximum yield [ 215 ]. For instance, economic modelling via formula adjustment and production possibility curve (PPC) were performed to assess the carbon source for optimal culture medium composition and optimal productivity set (OPS) of L. acidophilus EPS production [ 215 ]. According to Lin et al [ 215 ], the total cost production of L. acidophilus EPS by using MRS-nutrient broth culture medium was able to reduce by 30% (USD 7.5/kg/L culture) as compared to MRS only (USD 11.0/kg/L culture).…”

Section: Challenges Of Lactobacillus Sams Applicatmentioning

confidence: 99%

“…For instance, economic modelling via formula adjustment and production possibility curve (PPC) were performed to assess the carbon source for optimal culture medium composition and optimal productivity set (OPS) of L. acidophilus EPS production [ 215 ]. According to Lin et al [ 215 ], the total cost production of L. acidophilus EPS by using MRS-nutrient broth culture medium was able to reduce by 30% (USD 7.5/kg/L culture) as compared to MRS only (USD 11.0/kg/L culture). Apart from that, statistical design is also one of the salient approaches that can be utilised to optimise media composition for the maximum yield of lactobacilli SAMs.…”

Section: Challenges Of Lactobacillus Sams Applicatmentioning

confidence: 99%

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Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health

2020

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Human vagina is colonised by a diverse array of microorganisms that make up the normal microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from the healthy human vagina, this includes Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus iners, and Lactobacillus jensenii. These vaginal lactobacilli have been touted to prevent invasion of pathogens by keeping their population in check. However, the disruption of vaginal ecosystem contributes to the overgrowth of pathogens which causes complicated vaginal infections such as bacterial vaginosis (BV), sexually transmitted infections (STIs), and vulvovaginal candidiasis (VVC). Predisposing factors such as menses, pregnancy, sexual practice, uncontrolled usage of antibiotics, and vaginal douching can alter the microbial community. Therefore, the composition of vaginal microbiota serves an important role in determining vagina health. Owing to their Generally Recognised as Safe (GRAS) status, lactobacilli have been widely utilised as one of the alternatives besides conventional antimicrobial treatment against vaginal pathogens for the prevention of chronic vaginitis and the restoration of vaginal ecosystem. In addition, the effectiveness of Lactobacillus as prophylaxis has also been well-founded in long-term administration. This review aimed to highlight the beneficial effects of lactobacilli derivatives (i.e. surface-active molecules) with anti-biofilm, antioxidant, pathogen-inhibition, and immunomodulation activities in developing remedies for vaginal infections. We also discuss the current challenges in the implementation of the use of lactobacilli derivatives in promotion of human health. In the current review, we intend to provide insights for the development of lactobacilli derivatives as a complementary or alternative medicine to conventional probiotic therapy in vaginal health.

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