Optimal, Efficient Reconstruction of Phylogenetic Networks With Constrained Recombination

Abstract

A phylogenetic network is a generalization of a phylogenetic tree, allowing structural properties that are not tree-like. In a seminal paper, Wang et al.(1) studied the problem of constructing a phylogenetic network, allowing recombination between sequences, with the constraint that the resulting cycles must be disjoint. We call such a phylogenetic network a "galled-tree". They gave a polynomial-time algorithm that was intended to determine whether or not a set of sequences could be generated on galled-tree. Unfortunately, the algorithm by Wang et al.(1) is incomplete and does not constitute a necessary test for the existence of a galled-tree for the data. In this paper, we completely solve the problem. Moreover, we prove that if there is a galled-tree, then the one produced by our algorithm minimizes the number of recombinations over all phylogenetic networks for the data, even allowing multiple-crossover recombinations. We also prove that when there is a galled-tree for the data, the galled-tree minimizing the number of recombinations is "essentially unique". We also note two additional results: first, any set of sequences that can be derived on a galled tree can be derived on a true tree (without recombination cycles), where at most one back mutation per site is allowed; second, the site compatibility problem (which is NP-hard in general) can be solved in polynomial time for any set of sequences that can be derived on a galled tree. Perhaps more important than the specific results about galled-trees, we introduce an approach that can be used to study recombination in general phylogenetic networks. This paper greatly extends the conference version that appears in an earlier work.(8) PowerPoint slides of the conference talk can be found at our website.(7).

Reconstruction of certain phylogenetic networks from the genomes at their leaves

“…Wang et al then considered a restricted problem in which all recombination events are associated with nodedisjoint recombination cycles. Gusfield et al (2004a) gave necessary and sufficient conditions to identify these networks, which they called ''galled-trees,'' and they added a much more specific and realistic model of recombination events. Gusfield et al (2004b) gave a more detailed study of these node-disjoint cycles.…”

Reconstructing Phylogenetic Level-1 Networks from Nondense Binet and Trinet Sets

“…2 below). This type of network was first considered in [20] and is closely related to so-called galled-trees [3,7]. Level-1 networks have been used to, for example, analyse virus evolution [10], and are of practical importance since their simple structure allows for efficient construction [7,10,15] and comparison [17].…”

Unique Solvability of Certain Hybrid Networks from Their Distances

“…They then consider a restricted problem in which all recombination events are associated with node-disjoint recombination cycles, and they present a sufficient condition to identify such networks. Gusfield et al [2] give necessary and sufficient conditions to identify these networks, which they call "galled-trees," and they add a much more specific and realistic model of recombination events. In [3] they give a more detailed study of these node-disjoint cycles.…”

“…Thus, for extant taxa u and v we typically assume a distance d(u, v) that measures the evolutionary change between u and v. Like Wang et al [15] and Gusfield et al [2] this paper models only the case of binary characters in rooted acyclic directed graphs. Unlike [15] and [2] we shall assume that the network itself is given. We then study the problem of inferring complete distance information (such as all the branch lengths) within the network.…”