Optimal electron‐beam treatment planning for retinoblastoma using a new three‐dimensional Monte Carlo‐based treatment planning system

Al-Beteri, A.A.; Raeside, D. E.

doi:10.1118/1.596886

Cited by 18 publications

(7 citation statements)

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“…The necessity of accurate electron dose calculation has motivated many efforts to develop Monte Carlo electron beam treatment planning systems. 6,7,[17][18][19][20][21][22] Due to the rapid development of computer technology and the employment of innovative variance reduction techniques, it is expected that treatment planning systems utilizing a Monte Carlo dose engine will begin to serve in routine clinical practice in the next few years. 6,7,[20][21][22][23][24][25][26][27][28][29] The commissioning procedure for a Monte Carlo treatment planning system can be different from that for a conventional planning system, since it requires more detailed and accurate clinical beam data.…”

Section: Introductionmentioning

confidence: 99%

Electron beam modeling and commissioning for Monte Carlo treatment planning

Jiang

Kapur

2000

Medical Physics

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A hybrid approach for commissioning electron beam Monte Carlo treatment planning systems has been studied. The approach is based on the assumption that accelerators of the same type have very similar electron beam characteristics and the major difference comes from the on-site tuning of the electron incident energy at the exit window. For one type of accelerator, a reference machine can be selected and simulated with the Monte Carlo method. A multiple source model can be built on the full Monte Carlo simulation of the reference beam. When commissioning electron beams from other accelerators of the same type, the energy spectra in the source model are tuned to match the measured dose distributions. A Varian Clinac 2100C accelerator was chosen as the reference machine and a four-source beam model was established based on the Monte Carlo simulations. This simplified beam model can be used to generate Monte Carlo dose distributions accurately (within 2%/2 mm compared to those calculated with full phase space data) for electron beams from the reference machine with various nominal energies, applicator sizes, and SSDs. Three electron beams were commissioned by adjusting the energy spectra in the source model. The dose distributions calculated with the adjusted source model were compared with the dose distributions calculated using the phase space data for these beams. The agreement is within 1% in most of cases and 2% in all situations. This preliminary study has shown the capability of the commissioning approach for handling large variation in the electron incident energy. The possibility of making the approach more versatile is also discussed.

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Section: Introductionmentioning

confidence: 99%

Electron beam modeling and commissioning for Monte Carlo treatment planning

Jiang

Kapur

2000

Medical Physics

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“…(19) for electrons from the squaring ring sources. For direct electrons, there are other accelerator components in their paths from the virtual point source to the scoring plane in addition to the intervening air, such as the exit window, scattering foil, monitor chamber, mirror and protection window.…”

Section: Beam Reconstructionmentioning

confidence: 99%

Energy- and Intensity-Modulated Electron Beam for Breast Cancer

Chang¹

2000

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SUPPLEMENTARY NOTES 12a. DISTRIBUTION/ AVAILABILITY STATEMENTApproved for public release distribution unlimited 12b. DISTRIBUTION CODE ABSTRACT (Maximum 200 Words)In this project, we investigate energy-and intensity-modulated radiotherapy (EIMRT) for breast cancer to deliver dose distributions that closely match the target volume and minimize the dose to critical normal structures. We have worked on the following tasks: (1) to characterize electron beams from Helium-filled accelerators for EIMRT, (2) to develop optimization algorithms for EIMRT using these electron beams, (3) to verify these optimized dose distributions using the Monte Carlo simulation technique, and (4) to compare the optimized dose plans obtained by EIMRT with conventional treatment plans and those obtained by photon intensity-modulated radiotherapy (IMRT). During the second year research, we have performed accurate Monte Carlo simulations of the electron beams in He-filled accelerators and also investigated the effect of magnetic field modulation. Our results demonstrated that electron beams could be modulated more effectively using an electron MLC and a 1.5 T magnetic field to deliver superior dose distributions for EIMRT. We have tested different algorithms for "Inverse treatment planning" to optimize breast treatment plans for EIMRT. The results confirmed that EIMRT is superior to photon IMRT and much more effective then conventional tangential photon treatments. Further studies will be performed to verify the dose plans for realistic patients. The outcome will determine whether EIMRT offers a significant advantage over conventional photon/electron treatment and over photon IMRT. SUBJECT TERMS IntroductionThis project is aimed at exploring energy-and intensity-modulated electron beams for breast cancer treatment to deliver optimized conformal radiotherapy dose distributions that closely match the target volume and minimize the dose to critical normal structures. We have proposed to work on the following tasks: (1) to characterize electron beams from Helium-filled accelerators, (2) to develop optimization algorithms for energy-and intensity-modulated radiotherapy (EEV1RT) using these electron beams, (3) to verify these optimized dose distributions using the Monte Carlo simulation technique, and (4) to compare the optimized dose plans obtained by EIMRT with conventional treatment plans and those obtained by photon intensity-modulated radiotherapy (EVIRT). BodyAlthough photon beams have been an effective modality for breast cancer treatment in radiation therapy the following problems (or potential areas of improvement) remain: (1) the inclusion of the lung and sometimes of a small volume of the heart in the high-dose volume due to tumor location, patient size or in the case of chest-wall treatments; (2) lower dose near the skin surface due to lack of electron build-up in a photon beam; and (3) high exit or scatter dose to the normal structures such as the lung and heart, and more importantly the contralateral breast, which may be a major ca...

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“…However, in radiation therapy centers in which adequate facilities for brachytherapy and proton therapy do not exist, electron or photon beam therapy is also used for treating ocular melanoma vejdani@neyshabur.ac.ir (Inoue et al, 2014). Several authors have studied the performance of electron beam therapy for treating different types of eye melanomas (Al-Beteri and Raeside, 1992;Blach et al, 1996;Lee et al, 2005). Lee et al (2005) compared the dose distribution and dose volume histograms (DVHs) for photon therapy, electron therapy, intensity-modulated radiation therapy and standard proton therapy.…”

Section: Introductionmentioning

confidence: 99%

Dose calculation of different eye substructures using a realistic eye model when treating ocular tumors with electron therapy

et al. 2016

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One of the most frequent types of intraocular melanoma in adults is choroidal uveal melanoma. The most commonly used forms of radiation therapy are ophthalmic plaque brachytherapy and charged particle external radiation therapy. In the absence of adequate facilities for brachytherapy and proton therapy, electron therapy would be an efficient radiation therapy technique for treating eye melanomas. In the present work, the Monte Carlo code MCNPX 2.6.0 was used to calculate the dose distribution to substructures of the eye in electron therapy of three common choroidal tumors. The simulations were performed for 6 electron beams with nominal energies between 5 MeV and 10 MeV and also for 10 incidence angles. To identify suitable treatment plans, the tumor-to-sensitive zone dose ratios were estimated. Moreover, the equivalent doses delivered to healthy substructures of the eye were also calculated. The results indicate that for the treatment of tumors located at the posterior part of the eye, an electron beam with energy of 10 MeV and incident angle of 45 • relative to the eye axis provides the best tumor coverage while optimally sparing other eye substructures. In addition, for tumors positioned on the upper and lower parts of the vitreous, electron beams with energy of 10 MeV, an azimuthal angle of 270 • , and polar incident angles of 90 • and 105 • , respectively, lead to appropriate dose delivery.

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Optimal electron‐beam treatment planning for retinoblastoma using a new three‐dimensional Monte Carlo‐based treatment planning system

Cited by 18 publications

References 0 publications

Electron beam modeling and commissioning for Monte Carlo treatment planning

Electron beam modeling and commissioning for Monte Carlo treatment planning

Energy- and Intensity-Modulated Electron Beam for Breast Cancer

Dose calculation of different eye substructures using a realistic eye model when treating ocular tumors with electron therapy

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