An experimental feasibility study was conducted on Magnetoacoustic-Tomography with Magnetic Induction (MAT-MI). It is demonstrated that the 2-dimensional (2D) MAT-MI system can detect and image the boundaries between regions of different electrical conductivity with high spatial resolution. Utilizing a magnetic stimulation coil, MAT-MI evokes magnetically induced eddy current in an object which is placed in a static magnetic field. Because of the existence of Lorenz forces, the eddy current in turn causes acoustic vibrations, which are measured around the object in order to reconstruct the electrical impedance distribution of the object. The present experimental results from the saline and gel phantoms are promising and suggest the merits of MAT-MI in imaging electrical impedance of biological tissue with high spatial resolution.Magnetoacoustic Tomography with Magnetic Induction (MAT-MI) is an imaging modality combining pulsed magnetic stimulation with sonography and it is proposed for imaging the electrical impedance of samples noninvasively 1 . Noninvasive measurement of electrical properties of biological tissue has drawn substantial research interest for decades and a variety of techniques has been developed such as Electrical impedance tomography (EIT) 2-4 , Magnetic Resonance Electrical Impedance Tomography (MREIT) 5-7 , and Magnetic Induction Tomography (MIT) 8, 9 . In addition, Magnetoacoustic Tomography (MAT) 10, 11 and Hall Effect Imaging (HEI) 12, 13 have both been reported for combining bioelectromagnetism together with sonography.In the MAT-MI approach we investigated here, pulsed magnetic stimulation (μs) is imposed on an object placed in a static magnetic field. The magnetically induced eddy current is then subject to Lorenz force. The Lorenz force causes acoustic vibrations which can be measured to reconstruct the conductivity distribution of the sample. Denoting the static magnetic field as B 0 , the magnetically induced current density distribution as J̃ (the tilt over a variable indicates a function of time; otherwise, the variable is not a function of time if not denoted explicitly), the Lorenz force can be described as J̃ × B 0 . The wave equation governing the pressure distribution p̃ can be written in equation (1) 11 (1)
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NIH-PA Author Manuscriptwhere c s is the acoustic speed in the media. In equation (1), J(r, t) = J(r)δ(t), with an assumption that the induced eddy current has an ideal pulsed distribution over time. This would be a reasonable approximation as long as the excitation coil is sending pulse stimulations that are short enough. Using Green's function, the solution of equation (1) can be written as in (2): (2) where R = |r − r′|, and V is the volume containing the acoustic source. The pressure on a surface surrounding the object can be measured to reconstruct the source term ∇ · (J × B 0 ) using the time reversing technique 1, 14 as in equation (3):where r d is a point on the detection surface Σ, n is the normal vector of...