“…Hence, the ideal transition probability is We can then apply a column vector [ P 11 ( t ) P 22 ( t )] T to estimate sequence similarity with the pair of AUSP ratios, ρ R and ρ L . The Euclidean distance estimation is used to screen the similarity, as follows [26]: where N is the number of sampling points within infinitely small time intervals, Δ t = t RL / N , n = 1, 2, 3,…, N . In time interval t RL , the joint probability accommodating the variance with AUSP ratios, ρ R and ρ L , is as follows: …”