Optimal fuzzy sliding-mode control for bio-microfluidic manipulation

Chung, Yung-Chiang; Wen, Bor-Jiunn; Lin, Yu‐Chen

doi:10.1016/j.conengprac.2007.01.005

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…Second, it was used in DNA extraction. In this section, DNA extraction from Chung, Wen and Lin (Chung, Wen & Lin, 2007) is introduced. The microfluidic DNA extraction chip was designed and fabricated onto a polymethylmethacrylate (PMMA) substrate with flow channels.…”

Section: Biomedical Application Resultsmentioning

confidence: 99%

A Biomedical Application by Using Optimal Fuzzy Sliding-Mode Control

Wen¹

2011

Sliding Mode Control

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Section: Biomedical Application Resultsmentioning

confidence: 99%

A Biomedical Application by Using Optimal Fuzzy Sliding-Mode Control

Wen¹

2011

Sliding Mode Control

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“…A pneumatic pump controlling system [43] was connected to the device and generated the oscillations of the sample solution. The solution flowing processes from hot region (T 2 ) to cold region (T 1 ) are schematically illustrated in Fig.…”

Section: Experimental Setup and Analysismentioning

confidence: 99%

Microfluidic chip of fast DNA hybridization using denaturing and motion of nucleic acids

et al. 2008

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This study presents the effect of fluidic temperatures and velocities on improving DNA hybridization. The efficiency of hybridization could be improved by introducing elevated temperature in the hot region and velocity in the cold region. Compared with the conventional methods, this hybridization microchip was able to increase the hybridization signal 4.6-fold within 30 min. The 1.4-kb single-stranded target DNA was tested. The increasing tendency of the fluorescence intensity was apparent when the temperature was higher than 82 degrees C, and the fluorescence intensity reached an asymptotic value at T>90 degrees C. A mathematical model was proposed to relate the fluorescence intensity of DNA hybridization with the hot-region temperature and the cold-region velocity. Based on these results, the new hybridization chip with the processes of temperature and velocity differences will improve efficiency of DNA detection. The microchip combined with hot-region temperature and cold-region bulk flow velocity effects could provide additional efficiency in DNA hybridization.

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“…A scanner (ScanArray 4000, GSI Lumonics, USA) was used to scan and analyze the hybridization results, which are shown in the images and fluorescence intensities. A pneumatic pump controlling system [18] was connected to the device and generated the oscillations of the sample solution. The solution flowing processes from hot region (T2) to cold region (T 1 ) are schematically illustrated in Figure 3.…”

Section: Hot Regionmentioning

confidence: 99%

Microfluidic chip of fast DNA hybridization using denature and motion of nucleic acids

Chung

Lin

Chueh

et al. 2009

2009 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

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We demonstrate that the efficiency of DNA hybridization could be improved by introducing elevated temperature in the hot region and higher velocities in the cold region of a microfluidic chip. Compared with the conventional methods, this hybridization microchip was shown to increase the hybridization signal 4.6-fold within 30 minutes using a 1.4 kb target DNA as the test material. The increase in fluorescence intensity was apparent when the temperature was higher than 82°C, and the fluorescence intensity reached an asymptotic value as T > 90°C. A mathematical model was proposed to relate the fluorescence intensity of DNA hybridization with the temperature of hot region and the velocity of cold region. Based on these results, the new hybridization chip with the processes of temperature and velocity differences will provide additional efficiency in DNA detection.

show abstract

Optimal fuzzy sliding-mode control for bio-microfluidic manipulation

Cited by 13 publications

References 25 publications

A Biomedical Application by Using Optimal Fuzzy Sliding-Mode Control

A Biomedical Application by Using Optimal Fuzzy Sliding-Mode Control

Microfluidic chip of fast DNA hybridization using denaturing and motion of nucleic acids

Microfluidic chip of fast DNA hybridization using denature and motion of nucleic acids

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