Contamination in water distribution network (DN) can be catastrophic if free residual disinfection is not present. To ensure drinking water quality in a DN, ensuring detectable levels of free residual chlorine is a common practice in most municipalities. Higher chlorine doses can be applied in this respect, but this can produce detrimental disinfection by‐products (DBPs) such as trihalomethane and Haloacetic acids, and chlorine‐related taste and odor complaints. Booster chlorination can be a possible solution in this regard where additional chlorine dosages are applied where free residual chlorine concentration is less or zero. However, that requires optimization studies to balance various issues related to over chlorination including higher cost related to installation and operation, higher DBPs, and taste and odor complaints. These optimization studies can not only help us in selecting dosages but also can help us in various other aspects including locating booster stations, deciding number of stations, and pumping scheduling. Unlike other optimization studies, booster chlorination‐related optimization studies also require appropriate variables, kinetics, objective functions, constraints, mathematical formulation, algorithm selection, and proper optimization operation. This article will highlight details of all these steps specific to booster chlorination.