Optimal Management of Calvarial Lymphoma: A Meta-Analysis

Toyota, Eric B.; Taslimi, Shervin; Alkins, Ryan

doi:10.1016/j.wneu.2021.04.066

Cited by 3 publications

(17 citation statements)

References 49 publications

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“… 3 Patients present with painless scalp lesions with normal overlying skin and often endorse regional headache. 3 , 4 , 9 Neurologic symptoms including seizures, mental status changes, apraxia, and hemiparesis may be present as a result of intracranial extension or mass effect. 4 PCVL should be considered in a patient presenting with a scalp mass with or without headache or other neurologic symptoms.…”

Section: Discussionmentioning

confidence: 99%

“… 4 PCVL should be considered in a patient presenting with a scalp mass with or without headache or other neurologic symptoms. 3 , 9 …”

Section: Discussionmentioning

confidence: 99%

“…Neurologic symptoms vary by location and extent of disease. 3 , 4 , 9 The diagnosis is established with a combination of imaging and tissue biopsy of the identified mass. 3 , 9 PCVL is managed with surgical resection of the tumor, radiation therapy, systemic chemotherapy, or a combination of these therapies.…”

Section: Introductionmentioning

confidence: 99%

“… 3 , 4 , 9 The diagnosis is established with a combination of imaging and tissue biopsy of the identified mass. 3 , 9 PCVL is managed with surgical resection of the tumor, radiation therapy, systemic chemotherapy, or a combination of these therapies. 4 , 6 , 9 , 12 The optimal treatment approach remains uncertain, however, given the rarity of this entity and limited reports of long-term follow-up.…”

Section: Introductionmentioning

confidence: 99%

“… 3 , 9 PCVL is managed with surgical resection of the tumor, radiation therapy, systemic chemotherapy, or a combination of these therapies. 4 , 6 , 9 , 12 The optimal treatment approach remains uncertain, however, given the rarity of this entity and limited reports of long-term follow-up. 4 We present a case of PCVL successfully treated with CNS-centric systemic chemoimmunotherapy (CIT).…”

Section: Introductionmentioning

confidence: 99%

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Successful CNS-Centric Therapeutic Management and Genomic Profiling of Primary Cranial Vault Diffuse Large B-Cell Lymphoma

Davis

Kimbrough

Moustafa

et al. 2023

JBM

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Primary cranial vault lymphoma (PCVL) is a rare lymphoma involving the skull with or without extra- and intracranial extension. Most cases of PCVL are diffuse large B-cell lymphoma (DLBCL). We report a case of primary cranial vault diffuse large B-cell lymphoma (PCV-DLBCL) that was successfully treated with anthracycline-based chemoimmunotherapy (CIT) alternating with central nervous system (CNS)-directed CIT with high-dose methotrexate and high-dose cytarabine. CNS-centric therapy was given for suspected cerebral cortical involvement and presumed elevated risk of CNS recurrence. The patient has remained in complete remission for 4.25 years following treatment. We suggest that PCV-DLBCL is potentially curable with CNS-directed therapy. Additionally, we provide genomic profiling results indicating an indeterminate cell of origin and multiple genetic mutations which are not frequently seen in DLBCL.

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Section: Discussionmentioning

confidence: 99%

“… 4 PCVL should be considered in a patient presenting with a scalp mass with or without headache or other neurologic symptoms. 3 , 9 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Successful CNS-Centric Therapeutic Management and Genomic Profiling of Primary Cranial Vault Diffuse Large B-Cell Lymphoma

Davis

Kimbrough

Moustafa

et al. 2023

JBM

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Case Report: Treatment of the rare B-cell lymphoblastic lymphoma with scalp lesion using rotation flap

Kim,

Jung,

Buckner-Wolfson

et al. 2023

Front. Oncol.

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IntroductionLeukemia is the most frequently occurring cancer in children, and lymphoblastic lymphoma (LBL) is a rare subtype. LBL are lymphoid neoplasms of B or T cell origin and are primarily treated with chemotherapy. Although cure rates among children are excellent, these patients must be monitored for relapse. Cutaneous lesions involving B-cell LBL (B-LBL) are extremely rare and here we present a patient with a worsening B-LBL scalp mass who required radical surgical excision.Case reportA 6-year-old female patient with a history of a nontender scalp mass discovered at approximately 2-3 years of age was evaluated for resection of the nodule due to its size and treatment history. The patient was originally diagnosed with follicular lymphoma by punch biopsy; excision was successfully performed on this 4 cm lesion and upon examination of the skin biopsy did we get a diagnosis of B-LBL. Reconstruction of the scalp was done through the rotation flap method. The patient’s scalp healed well, and adjuvant chemotherapy was continued. There has been no reoccurrence.DiscussionHere we report the rarity of B-LBL cases involving extranodal involvement in the scalp. The most common reconstruction of scalp lesions has been using free flap from the anterolateral thigh (ALT) and latissimus dorsi (LD). Our case used the rotation flap, which has its functional and cosmetic benefits. The importance of monitoring this patient is emphasized due to the dangerous consequences of B-LBL relapse. Ultimately, our successful treatment and care of this rare case can be used as guidance for similar patients in the future.

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Primary Calvarial Lymphoma: A Case Report

Abdoh,

Ajlan,

Basurrah

et al. 2024

Cureus

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Calvarial lymphoma is radiologically similar in many respects to meningiomas, solid fibrous tumours, osteomyelitis, and metastatic carcinomas. Even though it is an extremely rare phenomenon, the initial suspicion and detection of calvarial lymphoma are paramount to establishing a correct diagnosis which helps to determine an appropriate management strategy.We present an illustrative rare case of primary calvarial lymphoma along with a literature review focusing on the best management strategy for this rare entity.A 45-year-old female presented to our center in March 2022. She had a history of forehead swelling, which was progressively increasing in size over time. The metastatic workup and bone marrow biopsy were negative. Initially, extensive surgery was planned to resect the lesion, but after a discussion with the multidisciplinary team, a biopsy of the lesion was taken, which revealed a large B-cell lymphoma.It is prudent to consider calvarial lymphoma in the differential diagnosis of a progressively growing skull lesion, which may obviate the need for large resective surgery. A biopsy plus chemoradiation may be all that is required.

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Optimal Management of Calvarial Lymphoma: A Meta-Analysis

Cited by 3 publications

References 49 publications

Successful CNS-Centric Therapeutic Management and Genomic Profiling of Primary Cranial Vault Diffuse Large B-Cell Lymphoma

Successful CNS-Centric Therapeutic Management and Genomic Profiling of Primary Cranial Vault Diffuse Large B-Cell Lymphoma

Case Report: Treatment of the rare B-cell lymphoblastic lymphoma with scalp lesion using rotation flap

Primary Calvarial Lymphoma: A Case Report

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