Optimal management of venous thromboembolism in advanced pancreatic cancer with low-molecular-weight heparin: current evidence

Abstract

Abstract:Former evidence delineates a strong correlation between cancer and venous thromboembolic events (VTEs). Of all the malignancies, pancreatic cancer confers the highest risk for developing VTE during the course of the disease. The role of primary thromboprophylaxis in the comprehensive treatment of pancreatic cancer remains unclear. We have conducted a systematic review to assess the role of primary thromboprophylaxis in pancreatic cancer. Literature searches included PUBMED, EMBASE, Cochrane Library, and the database of clinical trials in order to identify relevant publications. Seven publications that included 6,003 patients were analyzed in our systematic review. The systematic review of current literature indicates that thromboprophylaxis reduces the risk of VTE without increasing the risk of major bleeding. However, data regarding survival benefits are inconclusive.