Optimal oxygen saturation in premature infants

Chang, Meayoung

doi:10.3345/kjp.2011.54.9.359

Cited by 19 publications

(11 citation statements)

References 23 publications

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“…Notably, overuse/underuse of oxygen supply to preterm infants can harm them; thereby, SpO 2 was monitored in our Handy incubator and was maintained between 90 and 93% to avoid diseases. Pulse oximetry is an advantageous method of oxygenation monitoring, since it is continuous and noninvasive [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

A Handy Preterm Infant Incubator for Providing Intensive Care: Simulation, 3D Printed Prototype, and Evaluation

Zaylaa

Rashid

Shaib

et al. 2018

Journal of Healthcare Engineering

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Preterm infants encounter an abrupt delivery before their complete maturity during the third trimester of pregnancy. Polls anticipate an increase in the rates of preterm infants for 2025, especially in middle- and low-income countries. Despite the abundance of intensive care methods for preterm infants, such as, but not limited to, commercial, transport, embrace warmer, radiant warmer, and Kangaroo Mother Care methods, they are either expensive, lack the most essential requirements or specifications, or lack the maternal-preterm bond. This drove us to carry this original research and innovative idea of developing a new 3D printed prototype of a Handy preterm infant incubator. We aim to provide the most indispensable intensive care with the lowest cost, to bestow low-income countries with the Handy incubator's care, preserve the maternal -preterm's bond, and diminish the rate of mortality. Biomedical features, electronics, and biocompatible materials were utilized. The design was simulated, the prototype was 3D printed, and the outcomes were tested and evaluated. Simulation results showed the best fit for the Handy incubator's components. Experimental results showed the 3D-printed prototype and the time elapsed to obtain it. Evaluation results revealed that the overall performance of Kangaroo Mother Care and the embrace warmer was 75 ± 1.4% and 66.7 ± 1.5%, respectively, while the overall performance of our Handy incubator was 91.7 ± 1.6%, thereby our cost-effective Handy incubator surpassed existing intensive care methods. The future step is associating the Handy incubator with more specifications and advancements.

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Section: Discussionmentioning

confidence: 99%

A Handy Preterm Infant Incubator for Providing Intensive Care: Simulation, 3D Printed Prototype, and Evaluation

Zaylaa

Rashid

Shaib

et al. 2018

Journal of Healthcare Engineering

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“…The use of controlled and limited SaO 2 induced a reduction in the incidence of severe ROP (22), but there was an increase in mortality (23). Wallance et al (24) tried to establish the incidence of severe ROP with the use of slightly reduced levels of oxygen saturation of 90-96% in the first few weeks of life.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Oxygen Therapy on the Development of Retinopathy of Prematurity

Jojić¹,

Predojević-Samardžić²,

Mavija³

et al. 2015

Pedaiatr Today

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Objective -The aim of this study is to show the effect of oxygen therapy in premature babies on the development of severe ROP. Materials and methods -This retrospective research covered a period of two years, and included 108 premature babies, with birth weight <1500 g and gestational age <33 weeks, at the Children's Ward of the University Hospital Clinical Centre, Banja Luka. The effects of the length of oxygen therapy and episodes of hypoxia and hyperoxia on the development of severe ROP were analysed. Results -ROP was present in 64 (59.2%) newborns, of which 21 (19.4%) had severe ROP. The incidence of severe ROP is statistically higher with lower birth weight, <1150 g (p<0.01), lower gestational age <30 weeks, longer oxygen therapy and when there were frequent episodes of hyperoxia and hypoxia. By multiple logistic regression analysis, a very strong connection was established between severe ROP and exposure to episodes of hyperoxia (OR 32.73; CI 4.14-255.37), episodes of hypoxia (OR 14.08; CI 3.81-51.94), and oxygen therapy longer than 10 days (OR 15.54;. For most risk factors tested, there was a strong connection between severe ROP and birth weight <1250 g, gestational age <30 weeks, respiratory distress syndrome and perinatal asphyxia. Conclusion -Long-term oxygen therapy, prematurity and low birth weight with hypoxia are important factors in the development of severe ROP. Constant education is necessary of staff regarding the potentially harmful effects of oxygen in order to prevent both hypoxia and hyperoxia.

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“…lack of lung development following preterm birth or patent ductus arteriosus in which the ductus arteriosus fails to close after birth (144,145). Hypoxia in the premature neonate is generally associated with a harmful conditions requiring mechanical ventilation and oxygen therapy, GCs and other supplementary therapies (146,147). The adaptation of neonates to hypoxia requires a coordinated physiological response, which includes an increase in the release of GCs, but not aldosterone, from the adrenal cortex.…”

Section: Oxygen Deprivation During Birth and The Role Of Gcsmentioning

confidence: 99%

Bidirectional Crosstalk Between Hypoxia Inducible Factors and Glucocorticoid Signalling in Health and Disease

2021

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Glucocorticoid-induced (GC) and hypoxia-induced transcriptional responses play an important role in tissue homeostasis and in the regulation of cellular responses to stress and inflammation. Evidence exists that there is an important crosstalk between both GC and hypoxia effects. Hypoxia is a pathophysiological condition to which cells respond quickly in order to prevent metabolic shutdown and death. The hypoxia inducible factors (HIFs) are the master regulators of oxygen homeostasis and are responsible for the ability of cells to cope with low oxygen levels. Maladaptive responses of HIFs contribute to a variety of pathological conditions including acute mountain sickness (AMS), inflammation and neonatal hypoxia-induced brain injury. Synthetic GCs which are analogous to the naturally occurring steroid hormones (cortisol in humans, corticosterone in rodents), have been used for decades as anti-inflammatory drugs for treating pathological conditions which are linked to hypoxia (i.e. asthma, ischemic injury). In this review, we investigate the crosstalk between the glucocorticoid receptor (GR), and HIFs. We discuss possible mechanisms by which GR and HIF influence one another, in vitro and in vivo, and the therapeutic effects of GCs on HIF-mediated diseases.

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Optimal oxygen saturation in premature infants

Cited by 19 publications

References 23 publications

A Handy Preterm Infant Incubator for Providing Intensive Care: Simulation, 3D Printed Prototype, and Evaluation

A Handy Preterm Infant Incubator for Providing Intensive Care: Simulation, 3D Printed Prototype, and Evaluation

The Effect of Oxygen Therapy on the Development of Retinopathy of Prematurity

Bidirectional Crosstalk Between Hypoxia Inducible Factors and Glucocorticoid Signalling in Health and Disease

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