To improve the performance of pneumatic wheat seeding devices with the goal of achieving pneumatic wheat seeding in soil conditions with high moisture content and heavy clay texture in rice-wheat rotation areas, a simulation optimization study of a pneumatic wheat seeding device was carried out using computational fluid dynamics. In this model, airflow was described by ANSYS Fluent software as a continuous compressible gas phase. The effects of accelerating air pressure, throat distance and nozzle diameter on the steady airflow velocity, the steady airflow length and the inlet 2 negative pressure of airflow field were studied, and a response surface analysis was applied to optimize the pneumatic wheat seeding device. The optimal parameter combination was achieved, which was an acceleration pressure of 700 kPa, a throat distance of 20 mm, a nozzle diameter of 7.2 mm and an acceleration pressure of 700 kPa. Comparative verification results showed that the steady airflow velocity, the steady airflow length and inlet 2 negative pressure of the optimized pneumatic wheat seeding device were 718 m/s, 182 mm and 0.49 kPa by simulations, which were 37%, 3% and 17% greater than those of the original device, respectively. This finding illustrates that the CFD model could describe the characteristics of airflow field well in a pneumatic seeding device and that the regression model for parameter optimization was reliable. Numerical simulation of the airflow field based on CFD approach can provide a theoretical basis for improving the operating performance of a pneumatic seeding device.