2024
DOI: 10.1101/2024.02.01.578451
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Optimal Performance Objectives in the Highly Conserved Bone Morphogenetic Protein Signaling Pathway

Razeen Shaikh,
Nissa J. Larson,
Donny Hanjaya-Putra
et al.

Abstract: Throughout development, complex networks of cell signaling pathways drive cellular decision-making across different tissues and contexts. The transforming growth factor β (TGF-β) pathways, including the BMP/Smad pathway, play crucial roles in these cellular responses. However, as the Smad pathway is used reiteratively throughout the life cycle of all animals, its systems-level behavior varies from one context to another, despite the pathway connectivity remaining nearly constant. For instance, some cellular sy… Show more

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