Optimal Placement of Colectomy in the Treatment of Ulcerative Colitis: a Markov Model Analysis

Chu, Brandon K.; Scott, Frank I.; Bewtra, Meenakshi

doi:10.1007/s11605-021-05180-1

Cited by 3 publications

(1 citation statement)

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“…Given the continued emergence new UC therapies, finding the most appropriate treatment at the earliest opportunity may be paramount. The correct sequence of therapy remains an ongoing topic of research for many groups (1,(4)(5)(6)(7). Of note, most patients remained colectomy-free at 12 months after each switch.…”

Section: Discussionmentioning

confidence: 99%

Rate of Colectomy Increases Within 12 Months of Sequential Therapy for Ulcerative Colitis

et al. 2023

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INTRODUCTION:Patients with medically refractory ulcerative colitis who previously would have undergone surgery can now elect for subsequent medical therapy.METHODS:In a commercially insured population, we evaluated the proportion of patients initiating second-line, third-line, or fourth-line treatment who underwent colectomy in the following 12 months.RESULTS:Among 3,325 patients with ulcerative colitis, the colectomy rate within 12 months of a switch in therapy increased from 12% with the first switch to 17% and 19% with the second and third switches, respectively (P < 0.001).DISCUSSION:Treatment effectiveness declines with successive switching; however, even after initiating fourth-line therapy, most patients remain surgery-free.

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