The newly designed structures are employed to improve the high pressure turbine (HPT) disk to the expected performance. The twin-web disk (TWD) has been proven to be the future trend of the HPT disk due to its breakthrough in weight loss, strength and heat transfer efficiency compared to the conventional single web disk (SWD). Because of the multi-physics working conditions and intense coupling of multiple disciplines, the conventional design of the HPT disk is a labor intensive work. A series of design procedures, including asymmetrical computational fluid dynamics (CFD) analysis, inverse distance weighted (IDW) interpolation method, multidisciplinary feasible method (MDF), and design of experiments (DOE), are proposed to obtain the proper design for both TWD and SWD in an efficient way. In the present work, the multidisciplinary design of optimization (MDO) has been performed to find the proper shape of the TWD disk with the minimum mass. The results showed that the TWD exhibits a better performance in heat transfer and weight loss than SWD. The modeling and optimization procedure of this work can be referred for engineering design.