Optimal Serum Selenium Concentrations Are Associated with Lower Depressive Symptoms and Negative Mood among Young Adults

Conner, Tamlin S.; Richardson, Aimee C.; Miller, Jody C

doi:10.3945/jn.114.198010

Cited by 52 publications

(37 citation statements)

References 24 publications

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“…This may also explain why there was no difference found between patients who used extra supplementation and those who did not. Selenium deficiency may lead to cardiomyopathy, depressive symptoms or osteoarthropathy [30,31,32,33]. Elevated Phe values already put PKU patients at risk for mood disturbances [34,35].…”

Section: Discussionmentioning

confidence: 99%

Micronutrients, Essential Fatty Acids and Bone Health in Phenylketonuria

et al. 2017

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Introduction: In phenylketonuria (PKU), a natural protein-restricted dietary treatment prevents severe cognitive impairment. Nutrient deficiencies may occur due to strict diet. This study is aimed at evaluating the dietary intake and blood concentrations of micronutrients and essential fatty acids (FA), bone mineral density (BMD) and fracture history in patients on long-term dietary treatment. Methods: Sixty early diagnosed Dutch patients (aged 1-39 years) were included in a multi-center cross-sectional study. Their dietary intake, blood concentrations of micronutrients, FA, fracture history and BMD were assessed. Results: Selenium dietary intake and serum concentrations were low in 14 and 46% of patients, respectively. The serum 25-OH vitamin D2 + D3 concentration was low in 14% of patients while 20% of patients had a low vitamin D intake. Zinc serum concentrations were below normal in 14% of patients, despite adequate intake. Folic acid serum concentrations and intake were elevated. Despite safe total protein and fat intake, arginine plasma concentrations and erythrocyte eicosapentaenoic acid were below reference values in 19 and 6% of patients, respectively. Low BMD (Z-score <-2) was slightly more prevalent in patients, but the lifetime fracture prevalence was comparable to the general population. Conclusions: Dutch patients with PKU on long-term dietary treatment have a near normal nutrient status. Supplementation of micronutrients of which deficiency may be deleterious (e.g., vitamin D and selenium) should be considered. BMD warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Micronutrients, Essential Fatty Acids and Bone Health in Phenylketonuria

et al. 2017

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“…We introduced one at a time to the fully adjusted models of tables 2 and 3 variables representing inflammation (via log(C-reactive protein)), cardiovascular disease risk (via Framingham Global CVD Risk Score), reproductive history (via number of live births), and dietary elements associated with depression. The dietary variables consisted of folate, vitamin B12, zinc, vitamin D (Sarris et al, 2016) and selenium (Conner et al, 2015). Because 21 women who self-reported that they were 0 years postmenopause may actually have been perimenopausal by STRAW+10 criteria (Harlow et al, 2012), we conducted the analyses in Tables 2 and 3 again after excluding these women.…”

Section: Methodsmentioning

confidence: 99%

Do sex hormones or hormone therapy modify the relation of n-3 fatty acids with incident depressive symptoms in postmenopausal women? The MESA Study

Colangelo

Ouyang

Golden

et al. 2017

Psychoneuroendocrinology

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Introduction Considering that estradiol (E2) and n-3 polyunsaturated fatty acids (PUFAs) have roles in neurogenesis and in neurotransmission, we examined whether the association of PUFAs with incident depressive symptoms in postmenopausal women is modified by hormone therapy (HT) use or estrogen status. Methods Women (N=1616) free of depressive symptoms at baseline (2000-02) in the Multi-Ethnic Study of Atherosclerosis were classified by HT usage and quartiles of dietary eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the sum EPA+DHA. Women with serum E2 ≤0.073 nmol/L (sample median), were classified low on E2. Poisson regression was used to model incident depressive symptoms at examination 3 (2004-05), defined by the Center for Epidemiological Studies Depression Scale ≥16 or taking an antidepressant, first as a function of HT use and n-3 PUFA quartiles, and second, as a function of low E2 status and n-3 PUFA quartiles. Results Among HT non-users, positive, graded relationships (p-trends≤0.003) were found between PUFAs and incident depressive symptoms. Compared to the lowest quartile, the adjusted risk ratios (RRs) for the highest were 2.10, 2.39, and 2.04 for EPA, DHA, and EPA+DHA, respectively. For HT users, no associations were seen. When analyses were run for E2 status, the RRs over quartiles of the PUFAs were positive and graded for low E2 women, but were null for High E2 women. Conclusions Higher intakes of DHA and EPA were associated with higher risk of depressive symptoms in nonusers of HT, contrary to hypothesis.

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“…Besides, selenium plays an important role in relieving the mental/psychiatric stress. 25 It shows that selenium deprivation can cause depressed mood and hostile behavior. The turnover rate of some neurotransmitters has been affected by selenium deficiency.…”

Section: Physiological Functions Of Seleniummentioning

confidence: 99%

Selenium as a pleiotropic agent for medical discovery and drug delivery

Guan¹,

Yan²,

Li³

et al. 2018

IJN

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Selenium as a biologically active element lends much support to health maintenance and disease prevention. It is now presenting pleiotropic effects on therapy and drug delivery. In this study, a profiling on the physiological functions, therapeutic significances, clinical/preclinical performances, and biomedical and drug delivery applications of selenium in different modalities was carried out. Major interests focused on selenium-based nanomedicines in confronting various diseases pertaining to selenium or not, especially in antitumor and antidiabetes. Furthermore, the article exclusively discusses selenium nanoparticles featured by ameliorative functions with emphasis on their applications in medical practice and drug delivery. The state-of-the-art in medical discovery as well as research and development on selenium and nano-selenium is discussed in this review.

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Optimal Serum Selenium Concentrations Are Associated with Lower Depressive Symptoms and Negative Mood among Young Adults

Cited by 52 publications

References 24 publications

Micronutrients, Essential Fatty Acids and Bone Health in Phenylketonuria

Micronutrients, Essential Fatty Acids and Bone Health in Phenylketonuria

Do sex hormones or hormone therapy modify the relation of n-3 fatty acids with incident depressive symptoms in postmenopausal women? The MESA Study

Selenium as a pleiotropic agent for medical discovery and drug delivery

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