Optimal Skin Tolerance Dose Levels

Jolles, B.; Mitchell, R. G.

doi:10.1259/0007-1285-20-238-405

Cited by 52 publications

(8 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical concept that fi eld size infl uences the radiation response of the skin fi rst came from the publication in the 1940s of tables of skin tolerance doses for different areas of human skin exposed to orthovoltage radiation ( 30,31,33 ). The same dose delivered column indicating the fl uoroscopy time needed to cause each effect.…”

Section: Review: Radiation Effects Of Fluroscopy-guided Procedures Bamentioning

confidence: 99%

Fluoroscopically Guided Interventional Procedures: A Review of Radiation Effects on Patients’ Skin and Hair

Balter¹,

Hopewell²,

Miller³

et al. 2010

Radiology

508

398

View full text Add to dashboard Cite

Most advice currently available with regard to fluoroscopic skin reactions is based on a table published in 1994. Many caveats in that report were not included in later reproductions, and subsequent research has yielded additional insights. This review is a consensus report of current scientific data. Expected skin reactions for an average patient are presented in tabular form as a function of peak skin dose and time after irradiation. The text and table indicate the variability of reactions in different patients. Images of injuries to skin and underlying tissues in patients and animals are provided and are categorized according to the National Cancer Institute skin toxicity scale, offering a basis for describing cutaneous radiation reactions in interventional fluoroscopy and quantifying their clinical severity. For a single procedure performed in most individuals, noticeable skin changes are observed approximately 1 month after a peak skin dose exceeding several grays. The degree of injury to skin and subcutaneous tissue increases with dose. Specialized wound care may be needed when irradiation exceeds 10 Gy. Residual effects from radiation therapy and from previous procedures influence the response of skin and subcutaneous tissues to subsequent procedures. Skin irradiated to a dose higher than 3-5 Gy often looks normal but reacts abnormally when irradiation is repeated. If the same area of skin is likely to be exposed to levels higher than a few grays, the effects of previous irradiation should be included when estimating the expected tissue reaction from the additional procedure.

show abstract

Section: Review: Radiation Effects Of Fluroscopy-guided Procedures Bamentioning

confidence: 99%

Fluoroscopically Guided Interventional Procedures: A Review of Radiation Effects on Patients’ Skin and Hair

Balter¹,

Hopewell²,

Miller³

et al. 2010

Radiology

508

398

View full text Add to dashboard Cite

show abstract

“…His five-day point should be higher than the 1942 value (Ellis, private communication) owing to a meter which was reading low when the doses were given. Jolles and Mitchell (1947) used as their end-point moist desquamation of the treated area for small fields, followed by healing with routine dressings within four weeks from the end of treatment. Their treatments were given three or four times per week, and the horizontal extent of their points in Fig.…”

Section: Survey Of the Observational Datamentioning

confidence: 99%

“…Andrews and Coppedge (1951) surveyed over a dozen papers on cure of squamous cell carcinoma, and drew straight log-log regression lines of slope 0-22. They also drew regression lines of 0-32 through one point on the ordinate axis and the combined data of Ellis (1942) and Jolles and Mitchell (1947), representing normal tissue tolerance. This procedure is not altogether satisfactory; differences obtained by averaging two different sets of data may or may not be relevant.…”

Section: (C) Experiments On Skin Erythemamentioning

confidence: 99%

II. Dose-time Relationships in Radiotherapy and the Validity of Cell Survival Curve Models

Fowler¹,

Stern²

1963

BJR

113

View full text Add to dashboard Cite

“…Dose and time dependencies can be obtained from radiotherapy data for small field irradiations. Moist desquamation appears in 2 to 3 weeks in one-half of those that receive a dose of about 20 Gy to areas of about 35 to 80 cm2 (Andrews and Coppedge, 1951;Ellis, 1942;Jolles and Mitchell, 1947;Langham et al, 1967;Paterson, 1963;Archambeau, 1987). The most severe reaction occurs at around 3 weeks.…”

Section: -62mentioning

confidence: 99%

Health effects models for nuclear power plant accident consequence analysis: Low LET radiation: Part 2, Scientific bases for health effects models

Abrahamson¹,

Bender²,

Book³

et al. 1989

View full text Add to dashboard Cite

This report provides dose-response models intended to be used in estimating the radiological health effects of nuclear power plant accidents. Models of early and continuing effects, cancers and thyroid nodules, and genetic effects are provided. Two-parameter Weibull hazard functions are recommended for estimating the risks of early and continuing health effects. Three potentially lethal early effects-the hematopoietic, pulmonary and gastrointestinal syndromes-are considered. In addition, models are provided for assessing the risks of several non-lethal early and continuing effectsincluding prodromal vomiting and diarrhea, hypothyroidism and radiation thyroiditis, skin burns, reproductive effects, and spontaneous abortions. Linear and linear-quadratic models are recommended for estimating cancer risks. Parameters are given for analyzing the risks of seven types o f cancer in adults-leukemia, bone, lung, breast, gastrointestinal, thyroid and "other". The category, "other" cancers, is intended to reflect the combined risks of multiple myeloma, lymphoma, and cancers of the bladder, kidney, brain, ovary, uterus and cervix. Models of childhood cancers due to in utero exposure are also provided. For most cancers, both incidence and mortality are addressed. The models of cancer risk are derived largely from information summarized in B E I R 111-with some adjustment to reflect more recent studies. The effect of the revised dosimetry in Hiroshima and Nagasaki has not been considered.

show abstract

Optimal Skin Tolerance Dose Levels

Cited by 52 publications

References 1 publication

Fluoroscopically Guided Interventional Procedures: A Review of Radiation Effects on Patients’ Skin and Hair

Fluoroscopically Guided Interventional Procedures: A Review of Radiation Effects on Patients’ Skin and Hair

II. Dose-time Relationships in Radiotherapy and the Validity of Cell Survival Curve Models

Health effects models for nuclear power plant accident consequence analysis: Low LET radiation: Part 2, Scientific bases for health effects models

Contact Info

Product

Resources

About