Optimal gait design is important for micro-organisms and micro-robots that propel themselves in a fluid environment in the absence of external force or torque. The simplest models of shape changes are those that comprise a series of linked-spheres that can change their separation and/or their sizes. We examine the dynamics of three existing linked-sphere types of modeling swimmers in low Reynolds number Newtonian fluids using asymptotic analysis, and obatain their optimal swimming strokes by solving the Euler-Lagrange equation using the shooting method. The numerical results reveal that (1) with the minimal 2 degrees of freedom in shape deformations, the model swimmer adopting the mixed shape deformation modes strategy is more efficient than those with a singlemode of shape deformation modes, and (2) the swimming efficiency mostly decreases as the number of spheres increases, indicating that more degrees of freedom in shape deformations might not be a good strategy in optimal gait design in low Reynolds number locomotion. arXiv:1909.12952v1 [physics.flu-dyn]