Optimal surgical treatment of invasive lobular carcinoma of the breast

Chung, Maureen A.; Cole, Bernard F.; Wanebo, Harold J.; Bland, Kirby I.; Chang, Helena R.

doi:10.1007/bf02305534

Cited by 61 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several large retrospective studies demonstrate that when negative margins are obtained, the risk of IBTR is not significantly different between ILC and invasive ductal carcinoma. [53][54][55] Wider margins do not yield lower IBTR rates. In a retrospective study of 382 patients comparing margins [1 cm with smaller margins, no differences in local recurrence rates were observed.…”

Section: Radiation Therapy Deliverymentioning

confidence: 99%

Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer

et al. 2014

View full text Add to dashboard Cite

Purpose. Controversy exists regarding the optimal margin width in breast-conserving surgery for invasive breast cancer. Methods. A multidisciplinary consensus panel used a meta-analysis of margin width and ipsilateral breast tumor recurrence (IBTR) from a systematic review of 33 studies including 28,162 patients as the primary evidence base for consensus. Results. Positive margins (ink on invasive carcinoma or ductal carcinoma in situ) are associated with a two-fold increase in the risk of IBTR compared with negative margins. This increased risk is not mitigated by favorable biology, endocrine therapy, or a radiation boost. More widely clear margins than no ink on tumor do not significantly decrease the rate of IBTR compared with no ink on tumor. There is no evidence that more widely clear margins reduce IBTR for young patients or for those with unfavorable biology, lobular cancers, or cancers with an extensive intraductal component. Conclusion. The use of no ink on tumor as the standard for an adequate margin in invasive cancer in the era of multidisciplinary therapy is associated with low rates of IBTR and has the potential to decrease re-excision rates, improve cosmetic outcomes, and decrease health care costs.

show abstract

Section: Radiation Therapy Deliverymentioning

confidence: 99%

Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Principles of management for this lady are based on agreed consensus on locally advanced breast cancer (6,7). Pre-operatively, clinical staging for her left breast cancer was T4c and N2 whereas her right breast disease was assessed as T3 and N1.…”

Section: Discussionmentioning

confidence: 99%

“…She had adequate skin cover for primary closure post-mastectomy on the left side. In view of tumour clinically involving skin, nipple areolar complex and chest wall, she had clear indications for left mastectomy with axillary clearance, followed by adjuvant radio-chemotherapy (6).…”

Section: Discussionmentioning

confidence: 99%

A Case of Synchronous Bilateral Invasive Lobular Carcinoma of Breast

Mohamad¹

2014

View full text Add to dashboard Cite

show abstract

“…Mastectomy rates are higher in patients with ILC because of the high incidence rates of multifocality/multicentricity, the difficult assessment of margins status at operation [37,38], the larger size at diagnosis than IDC [19,33,34] and, finally, the lower clinical and pathological responses to neoadjuvant chemotherapy [39][40][41]. Nonetheless, breast conservative surgery is warranted by the introduction of MRI in the preoperative assessment of ILC extension and by the similar local recurrence rates after breast conservative surgery and mastectomy in patients with ILC [42,43].…”

Section: Management Of Ilcmentioning

confidence: 99%