“…Ž These include the work of Grossmann and coworkers Grossmann and Sargent, 1978;Halemane and Grossmann, 1983;Grossmann and Floudas, 1987;Pistikopoulos and Gross-. Ž mann, 1988a and others Acevedo and Pistikopoulos, 1998;Bansal et al, 2000;Mohideen et al, 1996;Pistikopoulos, 1995Pistikopoulos, , . 1997Ostrovsky et al, 1997 . Optimal design with unknown parameters is usually formulated by maximizing an objective function that represents the Ž .…”