Optimal Temperature for the Management of Severe Traumatic Brain Injury: Effect of Hypothermia on Intracranial Pressure, Systemic and Intracranial Hemodynamics, and Metabolism

Tokutomi, Takashi; Morimoto, Kazushige; Miyagi, Tomoya; Yamaguchi, Shintaro; Ishikawa, Kazufumi; Shigemori, Minoru

doi:10.1097/00006123-200301000-00013

Cited by 64 publications

(73 citation statements)

References 44 publications

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“…Hypothermie reduziert den zerebralen Blutfluss und Sauerstoffverbrauch; dies scheint bei erhöhtem intrakraniellem Druck nach Schädel-Hirn-Trauma zu den protektiven Effekten beizutragen [14]. Auf zellulä-rer Ebene kommt es zu gesteigerter Toleranz gegenüber ischämiebedingten Schä-digungen und auch zu verbesserter zellulärer Erholung nach fokaler Ischämie [9,15].…”

Section: Physiologische Effekteunclassified

Gezieltes Temperaturmanagement auf der Intensivstation

Jahn

Kaisers

2012

Anaesthesist

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Since October 2011 new guidelines exist for temperature management in critical care. According to the guidelines the term targeted temperature management (TTM) should replace the term therapeutic hypothermia. There is now a strong recommendation for TTM using 32-34°C as the preferred treatment for out-of-hospital adult cardiac arrest with a first registered electrocardiography rhythm of ventricular fibrillation or pulseless ventricular tachycardia and still unconscious after restoration of spontaneous circulation. A TTM of 32.5-35.5°C is also recommended for the treatment of term newborns who sustain asphyxia and exhibit acidosis and/or encephalopathy.

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Section: Physiologische Effekteunclassified

Gezieltes Temperaturmanagement auf der Intensivstation

Jahn

Kaisers

2012

Anaesthesist

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“…Minimierung der sekundären Hirnschä digung infolge Ödembildung und damit verbundener intrakranieller Druckerhö hung zum Ziel. Seit den 1990erJahren wurden mindestens 13 klinische, meist "SinglecenterStudien" bekannt, die den Einfluss der milden HT bei SHT unter sucht haben [8,9,10,11,12,13,14,15,16,17,18,19,20]. Wenngleich die Einschlusskri terien sowie auch die Hypothermie und Aufwärmzeiten z. T. differierten, konnte in nahezu allen Fällen übereinstimmend eine signifikante Senkung des intrakra niellen Druckes ("intracranial pressure", ICP) beschrieben werden.…”

Section: Schädel-hirn-traumaunclassified

Therapeutische Hypothermie auf der Intensivtherapiestation

Meixensberger

Renner

2007

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Experimental studies have demonstrated the neuroprotective effects of induced hypothermia in prevention of secondary insults following acute brain injury. Therefore, therapeutic hypothermia could be effective in the clinical setting of intensive care therapy. In this paper pathophysiological aspects of induced hypothermia are discussed and clinically relevant study results of hypothermia therapy are given in respect to evidence-based medicine.

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“…As an example of the type of study that might shed light on this issue, Tokutomi et al assessed the optimal temperature for the treatment of severe traumatic brain injury [54]. Modest hypothermia was capable of reducing ICP significantly, whereas no additional benefit was found at temperatures below 35°C.…”

Section: Depth Of Hypothermiamentioning

confidence: 99%

Therapy of Severe Ischemic Stroke: Breaking the Conventional Thinking

Schwab

2005

Cerebrovasc Dis

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Large hemispheric infarcts must be recognized in the emergency department as a life-threatening condition that requires prompt and massive intervention. After stabilization of the airway, breathing, and circulation, the initial diagnostic work-up and transfer to a neurointensive care unit should not be delayed. Today several new therapeutic options can be offered. Surgical decompression seems to be effective in lowering increased intracranial pressure, preventing transtentorial herniation and reducing mortality in patients with malignant middle cerebral artery infarction. Another option may be therapeutic hypothermia, which has been found to be neuroprotective in animal models, as well as in clinical studies after cardiac arrest. Experience in stroke patients suggest that hypothermia may offer a new approach for the treatment of acute cerebral ischemia.

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Optimal Temperature for the Management of Severe Traumatic Brain Injury: Effect of Hypothermia on Intracranial Pressure, Systemic and Intracranial Hemodynamics, and Metabolism

Cited by 64 publications

References 44 publications

Gezieltes Temperaturmanagement auf der Intensivstation

Gezieltes Temperaturmanagement auf der Intensivstation

Therapeutische Hypothermie auf der Intensivtherapiestation

Therapy of Severe Ischemic Stroke: Breaking the Conventional Thinking

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