Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

Werring, David J; Dehbi, Hakim-Moulay; Ahmed, Norin; Arram, Liz; Best, Jonathan G; Balogun, Maryam; Bennett, Kate; Bordea, Ekaterina; Caverly, Emilia; Chau, Marisa; Cohen, Hannah; Cullen, Mairead; Doré, Caroline J; Engelter, Stefan T; Fenner, Robert; Ford, Gary A; Gill, Aneet; Hunter, Rachael; James, Martin; Jayanthi, Archana; Lip, Gregory Y H; Massingham, Sue; Murray, Macey L; Mazurczak, Iwona; Nash, Philip S; Ndoutoumou, Amalia; Norrving, Bo; Sims, Hannah; Sprigg, Nikola; Vanniyasingam, Tishok; Freemantle, Nick; Jelley, Benjamin; Hughes, Tom; Evans, Mim; Esteban, Diego Garcia; Knibbs, Lucy; Broad, Lauren; Price, Rebecca; Griebel, Liz Hamer; Hewson, Sian; Thavanesan, Kamy; Mallon, Louise; Smith, Anna; White, Miranda; Zhang, Liqun; Clarke, Brian; Abousleiman, Youssif; Binnie, Lauren; Sim, Cai Hua; Castanheira, Margarida; Humphries, Fiona; Obarey, Sabaa; Feerick, Shez; Lee, Yee Chin; Lewis, Alex; Muhammad, Riham; Francia, Nina; Atang, Ndifreke; Banaras, Azra; Marinescu, Marilena; Ferdinand, Philip; Varquez, Resti; Ponce, Ida; Saxena, Surabhi; O'Brien, Eoin; Reyes, Juliana Delos; Mitchell-Douglas, Jennifer; Francis, Jobbin; Banerjee, Soma; Dave, Vaishali; Mashate, Sheila; Patel, Tulsi; Sekaran, Lakshmanan; Murad, Wahid; Asaipillai, Asokanathan; Sakthivel, Sethuraman; Tate, Margaret; Angus, Jane; Reid, Lisa; Fornolles, Caroline; Sundayi, Saul; Poolon, Lincy; Justin, Francis; Hunte, Sophy; Bhandari, Mohit; Kho, Jules; Cvoro, Vera; Parakramawansha, Ruwan; Couser, Mandy; Hughes, Hannah; Naqvi, Aaizza; Harkness, Kirsty; Richards, Emma; Howe, Jo; Kamara, Chris; Gardner, Jon; Bains, Harjit; Teal, Rachel; Joseph, Jeethu; Benjamin, Jithen; Al-Hussayni, Samer; Thomas, George; Robinson, Faye; Dixon, Lynn; Krishnan, Manju; Slade, Peter; Anjum, Tal; Storton, Sharon; Adie, Katja; Northcott, Keren; Morgan, Katie; Williams, Emilie; Chanashekar, Harinath; Maguire, Holly; Gabriel, Claire; Maren, Deborah; David, Hannah; Clarke, Sheron; Nagaratnam, Kiruba; Nelatur, Varun; Mannava, Neelima; Blasco, Lara; Devine, Joseph; Bathula, Rajaram; Gopi, Parvathy; Mehta, Niharika; Sreedevi Raj, Sreena; Teo, James; Sztriha, Laszio; Mah, Yee; Ankolekar, Sandeep; Sari, Beatrix; Tibajai, Maria; Morgan, Alicia; Recaman, Maria; Bayhonan, Samantha; Belo, Caroline; Finch, Sharon; Keenan, Samantha; Bowring, Angie; Shetty, Ashit; Chan, Siang; Gray, Lucy; Harrison, Thomas; Spooner, Oliver; Kinsella-Perks, Edward; Erumere, Esther; Sanders, Brittany; Sims, Don; Willmot, Mark; Littleton, Edward; Spruce, Elaine; Moody, Lisa; Sheriden, Christopher; Luxmore-Brown, Scott; Neal, Aoife; Beddows, Sophie; Tuna, Maria Assuncao; Misra, Amulya; Penn, Ruth; Mariampillai, Sonia; Anwar, Ijaz; Annamalai, Arunkumar; Whitehouse, Sarah; Shepherd, Lorna; Siddle, Elaine; Chatterjee, Kausik; Leason, Sandra; Davies, Angela; Marigold, Richard James; Frank, Sarah; Baird, Alix; Hannam-Penfold, Tomas; Inacio, Liliana; Smith, Simon; Eveson, David; Musarrat, Kashif; Khan, Shagufta; Harris, Tracy; Chowdhury, Muhibbur; Alam, Sajid; Jamieson, Elena; Anyankpele, Ebitare; Al Shalchi, Farah; Rivers, Vanessa; Bell, Stephanie; Francis, Rebecca; Beeby, Deborah; Finch, Jenny; Macleod, Mary Joan; Guzman-Gutierrez, German; Carter, Karla; Irvine, Janice; Gbadamoshi, Lukuman; Costa, Telma; Heirons, Sarah; Stoney, Hayley; Shaw, Louise; Choulerton, James; Catibog, Darwin; Sattar, Naweed; Myint, Min; Smith, Andy; Serac, Kwin; Emsley, Hedley; Sultan, Sulaiman; Gregary, Bindu; Brown, Allan; Mahmood, Afzal; Chattha, Navraj; Old, William; Pegg, Claire; Davey, Miriam; Page, Michelle; Sandhu, Banher; Phiri, Emily; Rashed, Khalid; Wilson, Elisabeth; Hindley, Esther; Board, Sarah; Antony, Sherly; Tanate, Alfonso; Davis, Michelle; Holland, Beth; Slater, Victoria; Fawcett, Michelle; England, Tim; Scott, James; Beavan, Jessica; Hedstrom, Amanda; Karunatilake, Dumin; Gillmain, Kimberley; Singh, Nishy; Hallows, Tracy; Barber, Mark; Yates, Luke; Micallef, Clayton; Esson, Derek; Meng Yu, Wai; Ming New, Benjamin Jaa; Matos, Alexandre; Burt, Clare; Cabrelli, Louise; Wilkie, Gillian; Meegada, Madana; Kirthivasan, Ramanathan; Fox, Caroline; Mead, Victoria; Lyle, Amanda; Saksena, Rajesh; Bakshi, Aashima; O'Kelly, Alison; Rehan, Jahanzeb; Ebueka, Osaretin; Cooper, Martin; Wynter, Inez; Smith, Susan; Kumar, Senthil; O'Brien, Linda; Parker, Cerrys; Parker, Emma; Khan, Numan; Patterson, Christopher; Maguire, Stuart; Quinn, Outi; Bellfield, Ruth; Behnam, Yousif; Costa, Janet; Padilla-Harris, Cheryl; Moram, Louise; Raza, Syed Abid; Tench, Helen; Sims, Tanya; McGuinness, Heather; Loosley, Ronda; Wolf-Roberts, Rebecca; Buddha, Sandeep; Salt, Irmak; Lewis, Kerry; Mavinamne, Sunanda; Ditchfield, Coleen; Dealing, Sharon; Shah, Alexander; Crossingham, Ginette; Mwadeyi, Memory; Kenton, Anthony; Omoregie, Faith; Abubakar, Saidu; Warwick, Allison; Hector, Gemma; Hassan, Ahamad; Veraque, Emelda; Farman, Michelle; Makawa, Linetty; Byrne, Anthony; Kirkham, Jackie; Blayney, Gareth; Selwyn, Jey; Kakar, Puneet; Al Khaddour, Mohammed; Dhami, Reena; Baker, Emelda; Esisi, Bernard; Clarkson, Emma; Fellowes, Dominic; Kresmir, Jergovic; Guyler, Paul; Ngo, David; Wijenayake, Indunil; Tysoe, Sharon; Galliford, Joanne; Harman, Paula; Garside, Mark; Badanahatti, Madhava; Smith, Anna; Riddell, Victoria; Gramizadeh, Gita; Dutta, Dipankar; Bajoriene, Milda; Erdogan, Hulya; Ward, Deborah; Doubal, Fergus; Samarasekera, Neshika; Risbridger, Sarah; MacRaild, Allan; Azim, Abul; Wood, Lisa; Tampset, Ruth; Shekhar, Raj; Rai, Umesh; Fuller, Tracy; Joshy, Aricsa; Nadar, Evelyn; Kini, Manohar; Ahmad, Syed; Robinson, Matthew; King, Lucia; Srinivasan, Venkatesan; Karwacka-Cichomska, Magdalena; Moore, Vicki; Smith, Kate; Kariyadil, Bincy; Kong, Kelvin; Hubbard, Kelly; Arif, Sarwat; Hasan, Muhammad; Temple, Natalie; Arcoria, Daniele; Horne, Zoey; Soe, Thandar; Wyllie, Hilary; Hacon, Christian; Sutherland, Helen; Menezes, Brian; Johnson, Venetia; Smyth, Nigel; Mehdi, Zehra; Tone, Ela; Bradley, Arian; Levell, Emma; Ekkert, Aleksandra; Mazzucco, Sara; McCafferty, Laura; Vonoven, Linda; Dewan, Suprita; Sridhar, Pagadala; Thomas, Jayne; Coetzee, Samantha; Icke, Becky; Williams, Jill; Saravanan, Narayanamoorthi; Bradley, Pamela; Gibson, Rebecca Marie; Antony, Jijimol; Ashraf, Imran; Mabuti, Jose; Kamundi, Charlotte; Patiola, Prasanna; Oakley, Naomi; Proeschel, Harold; Kelly, Debs; Longley, Wendy; Cave, Ashleigh; Ambrico, Carla; Black, Toby; Porretta, Elisa; Anthony, Alpha; Ragab, Suzanne; Dube, Judith; Kausar, Shahid; Gujjar, Abdullah; Abdullah, Mohammad; Kaur, Daljit; Gadapa, Naveen; Choudhary, Sumita; Nisar, Nabeela; Fawehinmi, Grace; Dunne, Karen; King, Sam; Kishore, Amit; Lee, Stephanie; Marsden, Tracy; Slaughter, Melanie; Cawley, Kathryn; Perez, Jane; Anderton, Peter; Soussi, Salem; Walstow, Deborah; Pugh, Rebecca; Manoj, Aravind; Fletcher, Glynn; Lopez, Paula; McCormick, Michael; Magee, Michael; Tallon, Grainne; McFarland, Denise; Cosgrove, Denise; Shinh, Naval; Metcalf, Kneale; Kostyuk, Alina; McDonald, Susan; Sayers, Sophie; Sayed, Walee; Abraham, Sam; Szabo, Gemma; Crosbie, Gareth; McIlmoyle, Jim; Fearon, Patricia; Courtney, Kerry; Tauro, Suzanne; Singh, Arun; Nair, Anand; Duberley, Stephen; Philip, Sheeba; Curley, Cath; Goddard, Wendy; Bridge, Luke; Willcoxson, Paul; Wanklyn, Peter; Owen, Jennifer; France, John; Reed, Bryony; Foulds, Angie; Richard, Bella; Parfitt, Louise; Affley, Brendan; Russo, Cristina; Dsouza, Margaret; Cruddas, Elizabeth; Hargroves, David; Rand, James; Shekar, Som; Bhat, Yaqoob; Marshall, Gail; Nash, Maxine; Ahmad, Nasar; Okoko, Blessing Oduh; Evans, Rachel; Taylor, Tegan; Dawson, Jesse; Colquhoun, Elizabeth; James, Christopher; Aguirre, Carlos; MacPhee, Catherine; Phipps, Janet; Ispoglou, Sissi; Hayes, Anne; Evans, Rachel

doi:10.1016/s0140-6736(24)02197-4

The Lancet

2024

DOI: 10.1016/s0140-6736(24)02197-4

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Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

David J Werring,

Hakim-Moulay Dehbi,

Norin Ahmed

et al.

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Cited by 5 publications

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Early vs later non–vitamin K antagonist oral anticoagulants in patients with acute ischemic stroke and atrial fibrillation: A meta-analysis and systematic review of randomized trials

Fu,

Hu,

Yang

et al. 2024

Heart Rhythm

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Early vs later non–vitamin K antagonist oral anticoagulants in patients with acute ischemic stroke and atrial fibrillation: A meta-analysis and systematic review of randomized trials

Fu,

Hu,

Yang

et al. 2024

Heart Rhythm

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Optimal anticoagulation timing after ischaemic stroke in patients with atrial fibrillation

Sandset,

de Sousa

2024

The Lancet

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When to start of anticoagulation after stroke and alternative thrombolytic agents: Highlights at World Stroke Congress 2024

Markus

2024

International Journal of Stroke

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Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

Cited by 5 publications

References 29 publications

Early vs later non–vitamin K antagonist oral anticoagulants in patients with acute ischemic stroke and atrial fibrillation: A meta-analysis and systematic review of randomized trials

Early vs later non–vitamin K antagonist oral anticoagulants in patients with acute ischemic stroke and atrial fibrillation: A meta-analysis and systematic review of randomized trials

Optimal anticoagulation timing after ischaemic stroke in patients with atrial fibrillation

When to start of anticoagulation after stroke and alternative thrombolytic agents: Highlights at World Stroke Congress 2024

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