“…Therefore, the cost function that minimized the change in hand force and torques used to generate the simulations may not be the one used by the nervous system during wheelchair propulsion. However, similar dynamic cost functions (minimizing change in torque and/or hand force) have frequently been used to successfully reproduce upper extremity movements (e.g., Uno et al, 1989;Nakano et al, 1999;Ohta et al, 2004;Svinin et al, 2005). In addition, the cost function used ensured a smooth, stable motion in both the joint and handrim coordinate frames while limiting co-contraction similarly to functions that are based on reduction of muscle activations, forces or stresses.…”