Optimal Treatment Planning for Skull Base Chordoma: Photons, Protons, or a Combination of Both?

Torres, Mylin A.; Chang, Eric L.; Mahajan, Anita; Lege, David G.; Riley, B.; Zhang, Xiaodong; Lii, M.; Kornguth, David; Pelloski, Christopher E.; Woo, Shiao Y.

doi:10.1016/j.ijrobp.2008.09.029

Cited by 42 publications

(19 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Torres reported a better target coverage with this combination in comparison to a single radiation modality, such as stereotactic photon therapy or pure proton therapy [57]. This protocol has shown to have almost identical benefits as pure proton irradiation for controlling chordomas [42][43][44].…”

Section: Radiation Therapymentioning

confidence: 91%

See 1 more Smart Citation

Chordomas of the skull base and cervical spine: clinical outcomes associated with a multimodal surgical resection combined with proton-beam radiation in 40 patients

et al. 2011

View full text Add to dashboard Cite

Previous studies of chordoma have focused on either surgery, radiotherapy, or particular tumor locations. This paper reviewed the outcomes of surgery and proton radiotherapy with various tumor locations. Between 2001 and 2008, 40 patients with chordomas of the skull base and cervical spine had surgery at our hospital. Most patients received proton therapy. Their clinical course was reviewed. Age, sex, tumor location, timing of surgery, extent of resection, and chondroid appearance were evaluated in regard to the progression-free survival (PFS) and overall survival (OS). The primary surgery (PS) group was analyzed independently. The extensive resection rate was 42.5%. Permanent neurological morbidity was seen in 3.8%. Radiotherapy was performed in 75% and the mean dose was 68.9 cobalt gray equivalents. The median follow-up was 56.5 months. The 5-year PFS and OS rates were 70% and 83.4%, respectively. Metastasis was seen in 12.5%. The tumor location at the cranio-cervical junction (CCJ) was associated with a lower PFS (P = 0.007). In the PS group, a younger age and the CCJ location were related to a lower PFS (P = 0.008 and P < 0.001, respectively). The CCJ location was also related to a lower OS (P = 0.043) and it was more common in young patients (P = 0.002). Among the survivors, the median of the last Karnofsky Performance Scale score was 80 with 25.7% of patients experiencing an increase and 11.4% experiencing a decrease. Multimodal surgery and proton therapy thus improved the chordoma treatment. The CCJ location and a younger age are risks for disease progression.

show abstract

Section: Radiation Therapymentioning

confidence: 91%

“…The mean dose was 68.9 (55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74) cobalt gray equivalent (CGE). In all but three cases, the radiation was proton-based.…”

Section: Radiation Adjuvant Therapymentioning

confidence: 99%

Chordomas of the skull base and cervical spine: clinical outcomes associated with a multimodal surgical resection combined with proton-beam radiation in 40 patients

et al. 2011

View full text Add to dashboard Cite

show abstract

“…[24][25][26][27] This meta-analysis did not identify a specific advantage of a particular radiation technique. Similarly, in their 10-year meta-analysis, Di Maio et al did not find a difference in OS among types of adjuvant radiation therapy, nor a difference in PFS between PBRT, stereotactic fractionated radiotherapy, or conventional radiation therapy.…”

Section: -23mentioning

confidence: 83%

Treatment and Outcome of Patients with Skull Base Chordoma: A Meta-Analysis

Amit¹,

Na’ara²,

Balan³

et al. 2014

J Neurol Surg B

View full text Add to dashboard Cite

“…Finally, PET may facilitate decision making when photon and proton irradiation are combined (66). On the one hand, particle therapy enables the assignment of highly conformal dose distributions, whereas photon therapy, on the other hand, is robust against motion and other sources of disturbance.…”

Section: Pet For In Vivo Treatment Verification Of Proton and Carbon mentioning

confidence: 99%

“…On the one hand, particle therapy enables the assignment of highly conformal dose distributions, whereas photon therapy, on the other hand, is robust against motion and other sources of disturbance. As a consequence, depending on the tumor entity and the availability of proton treatment facilities, a combination of protons and photons may be used (66).…”

Section: Pet For In Vivo Treatment Verification Of Proton and Carbon mentioning

confidence: 99%

Imaging-Based Treatment Adaptation in Radiation Oncology

2015

View full text Add to dashboard Cite

Learning Objectives: On successful completion of this activity, participants should be able to (1) understand the clinical implications of tumor characterization using different PET tracers before and during radiotherapy or chemoradiotherapy; (2) discuss the role of other functional imaging modalities (CT and MRI) in current oncology practice; and (3) introduce additional applications of PET imaging, such as in high-energy proton-beam therapy.

show abstract

Optimal Treatment Planning for Skull Base Chordoma: Photons, Protons, or a Combination of Both?

Cited by 42 publications

References 12 publications

Chordomas of the skull base and cervical spine: clinical outcomes associated with a multimodal surgical resection combined with proton-beam radiation in 40 patients

Chordomas of the skull base and cervical spine: clinical outcomes associated with a multimodal surgical resection combined with proton-beam radiation in 40 patients

Treatment and Outcome of Patients with Skull Base Chordoma: A Meta-Analysis

Imaging-Based Treatment Adaptation in Radiation Oncology

Contact Info

Product

Resources

About