The core of enterprise economic benefit evaluation lies in the development of a quantitative identification model. The Back Propagation (BP) neural network possesses robust parallel computing, adaptive learning, and error correction capabilities, which can effectively reveal the economic benefits of enterprises and their relationship with influencing factors. This study establishes an economic benefit evaluation model for express delivery enterprises based on the BP neural network. The model takes the annual profit rate of enterprises as the quantitative index of economic benefits and selects 13 factors, both external and internal, influencing the annual profit rate of express delivery enterprises as inputs for the BP neural network model. The economic benefit evaluation model based on BP neural network meets the requirement of objective mean square error in the 300th training cycle. The research results demonstrate that the BP model significantly saves computing time and enables rapid, comprehensive, and objective evaluation of the economic benefits of industrial enterprises.