2017
DOI: 10.1007/s12020-017-1245-1
|View full text |Cite
|
Sign up to set email alerts
|

Optimal vitamin D supplementation strategies

Abstract: Humans survived evolution without vitamin D-rich food or without vitamin D supplementation until vitamin D deficiency, rickets, became a major health problem from the 17th century onwards [1]. During the 20 th century, it became clear that exposure to sunlight and UVB should be avoided (infants and young children), or limited because of life time risks of skin damage or skin cancers. Moreover, voluntary avoidance (e.g. for cultural or religious reasons) of sun exposure or mismatch between skin color and climat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
15
0

Year Published

2017
2017
2022
2022

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 12 publications
(15 citation statements)
references
References 15 publications
0
15
0
Order By: Relevance
“…We argue that the current mouse models we have created, as well as additional models in preparation, will allow us to isolate the activities of each sphere of influence independently, thereby permitting a precise determination of not only the impact of locally produced 1,25(OH) 2 D 3 on the biological activities of NRTCs but of the dependence of these activities on circulating 1,25(OH) 2 D 3 produced by the kidney. This is important because a central clinical issue currently is the impact of vitamin D supplementation on 25(OH)D 3 levels that are hypothesized to represent a primary determinant of the local production of 1,25(OH) 2 D 3 (48,49). Of greater importance, however, is the fact that both spheres of vitamin D influence may also be altered in disease, as illustrated in chronic kidney disease (40), autoimmune disease (50), and cancer (51), where both genetic and epigenetic changes could affect both the production and utilization of 1,25(OH) 2 …”
Section: Endocrine Regulation Of Cyp27b1mentioning
confidence: 99%
“…We argue that the current mouse models we have created, as well as additional models in preparation, will allow us to isolate the activities of each sphere of influence independently, thereby permitting a precise determination of not only the impact of locally produced 1,25(OH) 2 D 3 on the biological activities of NRTCs but of the dependence of these activities on circulating 1,25(OH) 2 D 3 produced by the kidney. This is important because a central clinical issue currently is the impact of vitamin D supplementation on 25(OH)D 3 levels that are hypothesized to represent a primary determinant of the local production of 1,25(OH) 2 D 3 (48,49). Of greater importance, however, is the fact that both spheres of vitamin D influence may also be altered in disease, as illustrated in chronic kidney disease (40), autoimmune disease (50), and cancer (51), where both genetic and epigenetic changes could affect both the production and utilization of 1,25(OH) 2 …”
Section: Endocrine Regulation Of Cyp27b1mentioning
confidence: 99%
“…25 Low vitamin D levels are a public health concern, but the precise definition of deficiency and the method of supplementation to obtain optimal serum 25(OH)VitD levels are still open to debate. 26 For example, common advice is to reach and maintain a serum level Z75 nmol/L (Z30 ng/mL), which is the serum concentration associated with good bone health, optimal fracture reduction, and reduced likelihood of secondary hyperparathyroidism. Consequently, a serum concentration o50 nmol/L (o20 ng/L) is usually considered deficient and between 50 and 75 nmol/L insufficient.…”
Section: Beyond Building Bone What Is the Optimal Serum Vitamin D Stmentioning
confidence: 99%
“…The result is that vitamin D insufficiency affects 50% of the population worldwide. 1,13 Thus, reasonable vitamin D supplementation remains necessary for the most at-risk groups, 26 including, among others, adults aged Z65 years (and not only institutionalized and home-bound persons), 17 those with heavily pigmented skin, 1 or those with osteoporosis. 82 Both types of vitamin D (D 2 and D 3 ) supplements are available, and vitamin D 3 is the type that most experts believe should be used in practice.…”
Section: How To Optimize Vitamin D Status Efficiently and Safelymentioning
confidence: 99%
See 2 more Smart Citations