Optimasi Formula Mikroemulsi Berbahan Dasar Crude Palm Oil (CPO) Sebagai Antioksidan Potensial Pada Kulit

Abstract

Crude Palm Oil (CPO) is one of the typical Indonesian plant that has potential effect as an antioxidant preparation. The purpose of this study was to produce microemulsion with CPO content that had good physical characteristics and also showed antioxidant activity. This research was divided into 3 stages i.e. microemulsion formulation, physical characterization and stability, and antioxidant activity evaluation. The microemulsion was formulated using Phase Titration Method with CPO as oil phase, surfactant tween 80, cosurfactant PEG 400 and aquadest. The treatment in this study was the addition of CPO with various concentration of 5%, 7.5%, and 10% (w/w). The optimum formula was A1 which contained 5% (w/w) CPO. The results showed that this formula had a globule size of 288.87 ± 20.94 nm, zeta potential of -0.36 mV, density of 1.024 ± 6.15x10-5 g/mL, and pH in the range of 4.5-6.5. The microemulsion was stable in storage for 28 days at 25ºC, stable against extreme temperature changes and agitation. The CPO-based microemulsion had IC50 value of 10.5 μg/mL which showed strong antioxidant activity. It can be concluded that CPO-based microemulsion had good physical stability and antioxidant activity for further cosmetic preparation.

Development and characterization of clove oil microemulsion

“…However, if the amount of co-surfactant is elevated beyond the surfactant, a reduction in emulsification will occur, therefore, it is better to use more surfactant than co-surfactant (Sharma et al 2016). The results of this study mirror those of Syafitri et al (2020), who made microemulsion preparations with precise characteristics and good stability for seven days with a tween 80:PEG 400 ratio of 2:1. Fig.…”

“…A zeta potential measurements was carried out to measure the surface charge of the globules, which functioned to maintain optimum distance and prevent coalescence (Kale and Deore 2017). The optimum zeta potential value of the base microemulsion formulas ranged from +30mV to -30mV, with the most optimum value being close to 0 (Syafitri et al 2020). In the five formulas, the zeta potential values obtained met the required characteristics of a microemulsion preparation.…”