Operation of the G-Weike LC6090 CNC laser machine for cutting process uses the appropriate parameter settings in order to cut material optimally. It is known that CNC laser parameter settings on the machine are carried out by estimation or assumption because there is no reference or tabulation of parameter level settings on the machine which causes cutting process on the CNC laser to be less than optimal. Machine setting errors can result in mismatches of process results, so that the setting process is repeated on a trial error basis. This research is a continuation of previous research related to the optimization of the engraving process. This research focuses on optimizing the parameter setting level of the G-Weike LC6090 CNC laser machine for cutting process. The material used is acrylic with 3mm, 5mm, and 10mm thickness. The setting parameters used are cutting speed and laser power. The optimization method uses a combination of Simplex Centroid Design and multi-response plot optimization. The response parameters used are actual processing time, dimensions of the length and width of the cut. The results of this study indicate that the optimal level of cutting process settings for 3mm thickness acrylic is 1.93037mm / s for speed and 56.6963% for power. Acrylic with a thickness of 5mm obtained an optimal level setting of 2.6mm / s for speed and 55% for power. 10mm thick acrylic obtained the optimal setting level of 1.1535mm / s for speed and 59.539% for power. 59.539% for power.