Optimisation of a microwave‐assisted method for extracting withaferin A from <i>Withania somnifera</i> Dunal. using central composite design

Mirzajani, Fateme; Ghassempour, Alireza; Jalali‐Heravi, Mehdi; Mirjalili, Mohammad Hossein

doi:10.1002/pca.1230

Cited by 17 publications

(9 citation statements)

References 15 publications

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“…Conventional methods usually involve extensive drying followed by grinding into a fine powder. Next, aqueous or organic solvent‐based extraction procedures are performed where research suggests several ways in which extraction yields could be improved . For example, microwave‐assisted extraction can be optimized by modifying extraction time, temperature and solvent ratio.…”

Section: Bioactivity Of Withania Somnifera: Withaferin a And Other Wimentioning

confidence: 99%

Withania somnifera: From prevention to treatment of cancer

Palliyaguru

Singh

Kensler

2016

Molecular Nutrition Food Res

106

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The identification of bioactive molecules that have potential to interrupt carcinogenesis continues to garner research interest. In particular, molecules that have dietary origin are most attractive because of their safety, cost-effectiveness and feasibility of oral administration. Nutraceuticals have played an important role in the overall well-being of humans for many years, with or without rigorous evidence backing their health claims. Traditional medicine systems around the world have utilized plants for millennia that have medicinal properties, providing an opportunity for modern day researchers to assess their efficacies against ailments such as cancer. Withania somnifera (WS) is a plant that has been used in Ayurveda (an ancient form of medicine in Asia) and in the recent past, has been demonstrated to have anti-tumorigenic properties in experimental models. While scientific research performed on WS has exploded in the past decade, much regarding the mode of action and molecular targets involved remains unknown. In this review, we discuss the traditional uses of the plant, the experimental evidence supporting its chemopreventive potential as well as roadblocks that need to be overcome in order for WS to be evaluated as a chemopreventive agent in humans.

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Section: Bioactivity Of Withania Somnifera: Withaferin a And Other Wimentioning

confidence: 99%

Withania somnifera: From prevention to treatment of cancer

Palliyaguru

Singh

Kensler

2016

Molecular Nutrition Food Res

106

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“…Among them, 340 papers are categorized in the subject field of chemistry. The multivariate statistical methods are most used in chromatography, spectrophotometry, electrochemistry, and applied chemistry . Our search showed that there are only eight documents in the field of experimental design published by Iranian chemists from 2000 to 2004.…”

Section: Review Of Some Published Materials By Iranian Chemists In DImentioning

confidence: 99%

A perspective on the growth of chemometrics in Iran: a glance into activities between 2005 and 2012

Naseri

Bahram

2013

Journal of Chemometrics

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Although the first publications in the field of chemometrics by Iranian researchers go back nearly 23 years, Iran's chemometrics has experienced significant growth after the year 2000. More than 1500 papers have been published by Iranian chemometricians between 2005 and 2012 which is about seven times more than those published before 2005. The aim of this review is to present a perspective about Iran's chemometrics developments. The role of enthusiastic students, motivated professors, annual workshops, and international collaborations is discussed in this work. After introducing the first papers in each field of chememotrics, the papers published during 2005–2012 were screened, and some of them were introduced. Copyright © 2013 John Wiley & Sons, Ltd.

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“…To the best of our knowledge the quantification of SA and AVII in Atractylodes has not been reported so far. The parameters affecting UAE were optimised using central composite design (CCD; Du et al ., ; Mirzajiani et al ., ). The established method for simultaneous quantification of multicomponents in AMR proved to be a feasible method for quality control of AMR, and CCD showed ability in optimising the parameters affecting the efficiency of extracting sesquiterpenoids from AMR.…”

Section: Introductionmentioning

confidence: 97%