Optimisation of Cobalt Oxide Nanoparticles Synthesis as Bactericidal Agents

Moradpoor, Hedaiat; Safaei, Mohsen; Rezaei, Farzad; Golshah, Amin; Jamshidy, Ladan; Hatam, Reza; Abdullah, Rawand S.

doi:10.3889/oamjms.2019.747

Cited by 33 publications

(21 citation statements)

References 25 publications

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“…Due to the importance of metal NPs in the anticancer and antibacterial activities, special attention should be paid to optimizing their production with uniformed size and shapes. Numerous studies have been conducted to control the synthesis of Co 3 O 4 NPs, [51][52][53] and the present study is highly consistent with the previous results. Herein, the XRD pattern results show that Co 3 O 4 NPs are well crystallized which is consistent with the previous models of Liang et al, 54 Khan et al, 52 Chattopadhyay et al, 55 and Rahimi-Nasrabadi et al 50 The pattern illustrates the pure structure of Co 3 O 4 NPs synthesized by the sol-gel method.…”

Section: Discussionsupporting

confidence: 92%

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

Arsalan

Kashi

Hasan

et al. 2020

IJN

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The interaction of NPs with biological systems may reveal useful details about their pharmacodynamic, anticancer and antibacterial effects. Methods: Herein, the interaction of as-synthesized Co 3 O 4 NPs with HSA was explored by different kinds of fluorescence and CD spectroscopic methods, as well as molecular docking studies. Also, the anticancer effect of Co 3 O 4 NPs against leukemia K562 cells was investigated by MTT, LDH, caspase, real-time PCR, ROS, cell cycle, and apoptosis assays. Afterwards, the antibacterial effects of Co 3 O 4 NPs against three pathogenic bacteria were disclosed by antibacterial assays. Results: Different characterization methods such as TEM, DLS, zeta potential and XRD studies proved that fabricated Co 3 O 4 NPs by sol-gel method have a diameter of around 50 nm, hydrodynamic radius of 177 nm with a charge distribution of −33.04 mV and a welldefined crystalline phase. Intrinsic, extrinsic, and synchronous fluorescence as well as CD studies, respectively, showed that the HSA undergoes some fluorescence quenching, minor conformational changes, microenvironmental changes as well as no structural changes in the secondary structure, after interaction with Co 3 O 4 NPs. Molecular docking results also verified that the spherical clusters with a dimension of 1.5 nm exhibit the most binding energy with HSA molecules. Anticancer assays demonstrated that Co 3 O 4 NPs can selectively lead to the reduction of K562 cell viability through the cell membrane damage, activation of caspase-9,-8 and-3, elevation of Bax/Bcl-2 mRNA ratio, ROS production, cell cycle arrest, and apoptosis. Finally, antibacterial assays disclosed that Co 3 O 4 NPs can stimulate a promising antibacterial effect against pathogenic bacteria. Conclusion: In general, these observations can provide useful information for the early stages of nanomaterial applications in therapeutic platforms.

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Section: Discussionsupporting

confidence: 92%

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

Arsalan

Kashi

Hasan

et al. 2020

IJN

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“…The use of inorganic nanoparticles particularly metal nanoparticles (MNPs) and their oxides (e.g., ZnO [ 8 ], AgO [ 9 ], CuO [ 10 ], and CoO [ 11 ] NPs) has gained significant attention because of their promising results in targeted drug delivery [ 12 ], medical imaging [ 13 ], cancer treatment [ 14 , 15 ], and inhibiting bacterial growth [ 16 , 17 ] as well as promoting wound healing potential [ 18 ]. Furthermore, MNPs are desirable in fungicidal [ 19 ], and antimicrobial pharmaceuticals due to their durability, high stability, and low mammalian cell toxicity compared to organic NPs.…”

Section: Introductionmentioning

confidence: 99%

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

et al. 2021

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Background Increasing antibiotic resistance continues to focus on research into the discovery of novel antimicrobial agents. Due to its antimicrobial and wound healing-promoting activity, metal nanoparticles have attracted attention for dermatological applications. This study is designed to investigate the scope and bactericidal potential of zinc ferrite nanoparticles (ZnFe2O4 NPs), and the mechanism of anti-bacterial action along with cytocompatibility, hemocompatibility, and wound healing properties. Results ZnFe2O4 NPs were synthesized via a modified co-precipitation method. Structure, size, morphology, and elemental compositions of ZnFe2O4 NPs were analyzed using X-ray diffraction pattern, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy. In PrestoBlue and live/dead assays, ZnFe2O4 NPs exhibited dose-dependent cytotoxic effects on human dermal fibroblasts. In addition, the hemocompatibility assay revealed that the NPs do not significantly rupture red blood cells up to a dose of 1000 µg/mL. Bacterial live/dead imaging and zone of inhibition analysis demonstrated that ZnFe2O4 NPs showed dose-dependent bactericidal activities in various strains of Gram-negative and Gram-positive bacteria. Interestingly, NPs showed antimicrobial activity through multiple mechanisms, such as cell membrane damage, protein leakage, and reactive oxygen species generation, and were more effective against gram-positive bacteria. Furthermore, in vitro scratch assay revealed that ZnFe2O4 NPs improved cell migration and proliferation of cells, with noticeable shrinkage of the artificial wound model. Conclusions This study indicated that ZnFe2O4 NPs have the potential to be used as a future antimicrobial and wound healing drug.

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“…Moradpoor et al used three levels of Co (NO 3 ) 2 •6H 2 O and three levels of KOH stirred for different times to synthesize cobalt oxide nanoparticles with antibacterial activity. The obtained deposit was dried and calcined under specific conditions to obtain cobalt oxide nanoparticles [7]. In addition to the examples mentioned above, there are lots of researchers using chemical precipitation to synthesize cobalt oxide nanoparticles [10,11,19].…”

Section: Chemical Synthesismentioning

confidence: 99%

“…Metal oxide nanoparticles have been a research hotspot for decades in different fields, including medicine. Based on the emerging biological roles of cobalt, cobalt oxide nanoparticles (including CoO NPs, Co 2 O 3 NPs and Co 3 O 4 NPs) have been applied in different fields because of their special physical and chemical properties [7][8][9]. Cobalt oxide has been widely used for electrochemical applications due to its abundance in nature, feasible synthesis, easy-to-customize morphology and good chemical properties [10,11].…”

Section: Introductionmentioning

confidence: 99%

Inspirations of Cobalt Oxide Nanoparticle Based Anticancer Therapeutics

et al. 2021

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Cobalt is essential to the metabolism of all animals due to its key role in cobalamin, also known as vitamin B12, the primary biological reservoir of cobalt as an ultra-trace element. Current cancer treatment strategies, including chemotherapy and radiotherapy, have been seriously restricted by their side effects and low efficiency for a long time, which urges us to develop new technologies for more effective and much safer anticancer therapies. Novel nanotechnologies, based on different kinds of functional nanomaterials, have been proved to act as effective and promising strategies for anticancer treatment. Based on the important biological roles of cobalt, cobalt oxide nanoparticles (NPs) have been widely developed for their attractive biomedical applications, especially their potential for anticancer treatments due to their selective inhibition of cancer cells. Thus, more and more attention has been attracted to the preparation, characterization and anticancer investigation of cobalt oxide nanoparticles in recent years, which is expected to introduce novel anticancer treatment strategies. In this review, we summarize the synthesis methods of cobalt oxide nanoparticles to discuss the advantages and restrictions for their preparation. Moreover, we emphatically discuss the anticancer functions of cobalt oxide nanoparticles as well as their underlying mechanisms to promote the development of cobalt oxide nanoparticles for anticancer treatments, which might finally benefit the current anticancer therapeutics based on functional cobalt oxide nanoparticles.

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Optimisation of Cobalt Oxide Nanoparticles Synthesis as Bactericidal Agents

Cited by 33 publications

References 25 publications

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

Inspirations of Cobalt Oxide Nanoparticle Based Anticancer Therapeutics

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