Optimisation of floating matrix tablets and evaluation of their gastric residence time

Baumgartner, Stephan; Kristl, Julijana; Vrečer, Franc; Vodopivec, P.; Zorko, B.

doi:10.1016/s0378-5173(99)00378-6

Cited by 243 publications

(159 citation statements)

References 11 publications

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“…This incredible growth can be attributed to several advantages that these products offer, including improved patient compliance, better therapeutic efficiency, potential for cost saving and patentability, and opportunity for extending the product life-cycle. Oral sustained-release technology provides oral delivery for 24 h; however, in substances that cannot be well absorbed throughout the whole gastrointestinal tract, it may be disadvantageous (Baumgartner et al 2000). Extended-release dosage forms with prolonged residence times in the stomach are highly desirable for the drugs with narrow absorption windows, stability problems in the intestinal or colonic environments, locally acting in the stomach, and poor solubility in the intestine (Streubel, Siepmann, and Bodmeier 2003).…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of glipizide floating-bioadhesive tablets

Patel¹,

Chavda

2010

Braz. arch. biol. technol.

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Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of glipizide floating-bioadhesive tablets

Patel¹,

Chavda

2010

Braz. arch. biol. technol.

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“…Various approaches have been proposed to achieve gastric retention and includes co-administration of drugs or pharmaceutical excipients that influence the gastric motility pattern and thereby delay gastric emptying [4], magnetic systems [5], mucoadhesive systems [6], swelling or unfolding [7], density-controlled systems that either float on gastric contents [8] or sediment and combination systems [9]. Ritonavir (RN) is a protease inhibitor widely prescribed in antiretroviral regimen.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Gastroretentive Drug Delivery System for Ritonavir Tablets Using Natural Polymers

Chukka

Shaik

2017

Asian J Pharm Clin Res

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Objective: This study involves preparation and evaluation of floating tablets of ritonavir (RN) for improving the drug bioavailability by prolongation of gastric residence time. RN is an antiretroviral agent used in the treatment of HIV and viral diseases have been taken as a model drug in this investigation because of its low biological half-life (3-5 hrs). Moreover, it is primarily absorbed from stomach.Methods: RN floating tablets were prepared by the dry granulation technique, using guar gum and xanthan gum as polymers, sodium bicarbonate as effervescent agent, polyvinylpyrrolidone as binding agent, Dicalcium phosphate as diluents, crospovidone as swelling agent and magnesium stearate as lubricant. The prepared tablets were evaluated for various physicochemical parameters.Results: Drug-excipient interaction studies were conducted by Fourier transform infrared spectroscopy and differential scanning calorimetry. The results suggested that there was no incompatibility between the drug and polymers. The prepared tablets were evaluated for their physical characteristics. All the parameters were within the pharmacopoeial limits. Further, tablets were also studied for their floating properties and in vitro drug release characteristics. The tablets exhibited controlled and prolonged drug release profiles. The developed formulation was found to be stable. Conclusion:The developed floating tablets of RN exhibit prolonged release up to 12 hrs, and thus may improve bioavailability and minimize fluctuations in plasma drug concentrations.

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“…[2][3][4] In addition to this, recently, many researchers have been developing GRFDDS by optimization technique which utilizes optimum concentrations of combination of polymers to get product with desirable qualities. [5][6][7][8][9][10] This optimization technique provides the study of factors in all possible combinations with minimum experimentation and time [11] based on the design expert software, response surface methodology (RSM) graphs. This has been cited as a main reason for exploiting this technique as a promising tool to deliver drug at the site of absorption.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Prasanthi¹

2017

AJP

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Aim: The present study aimed at the development of valsartan floating tablets (VFTs) using Ocimum basilicum mucilage (OBM) and hydroxypropyl methylcellulose (HPMC) K100M by applying response surface methodologybased 3 2 factorial design. Materials and Methods: OBM (A) and HPMC K100M (B) were selected as independent factors, and swelling index (Y 1 ) and time taken for 90% drug release (Y 2 ) were as responses. Experimentally designed 9 runs assessed for Y 1 and Y 2 , and analysis of variance (ANOVA) was applied (P < 0.05) to define significant terms. Multicriterion decision approach anticipated optimized formulation VFT was developed and evaluated for physicochemical parameters such as weight variation, hardness, friability, thickness, and drug content. In vitro drug release and buoyancy studies, in vivo buoyancy studies, and Fourier transform infrared (FTIR) studies were carried out along with the validation of experimental design. Results and Discussion: Synergistic effect between polymers was observed in experimental runs, and ANOVA indicated a significant effect of A and B on Y 1 and Y 2 . Physicochemical parameters as well as floating lag time and total floating time of VFT were within the limits. FTIR studies unveiled drug and polymer compatibility. In vitro drug release studies demonstrated a good fit in zero-order and super Case-II transport drug release mechanism. Experimental values of VFT exhibited good agreement with predicted values generated by the software. In vivo buoyancy study in rabbit confirmed floatability of the VFT for 12 h. Conclusion: The present investigation concluded that statistically optimized VFT with OBM and HPMC K100M as rate retarding polymers exploiting as a promising formulation for gastric delivery of valsartan for longer periods.

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Optimisation of floating matrix tablets and evaluation of their gastric residence time

Cited by 243 publications

References 11 publications

Formulation and evaluation of glipizide floating-bioadhesive tablets

Formulation and evaluation of glipizide floating-bioadhesive tablets

Development and Characterization of Gastroretentive Drug Delivery System for Ritonavir Tablets Using Natural Polymers

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