Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir

Schwarz, Julia C.; Klang, Victoria; Karall, Sandra; Mahrhauser, Denise-Silvia; Resch, Guenter P.; Valenta, Claudia

doi:10.1016/j.ijpharm.2011.11.038

Cited by 68 publications

(34 citation statements)

References 22 publications

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“…[149][150][151][152][153][154][155][156][157][158] Further, the emulsion core compounds direct whether a single or multiple nanoemulsions can be formed based on their number of core compounds in the nanosized emulsions. 159,160 Multiple emulsions have advantages over single emulsions, due to their wider applications in cosmeceuticals, which can further reduce cosmeceutical cost. Several plant-derived bioactive compounds are used in nanoemulsions, such as flavonoids and polyphenols.…”

Section: Nanosingle or Multiemulsionsmentioning

confidence: 99%

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

148

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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Section: Nanosingle or Multiemulsionsmentioning

confidence: 99%

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

148

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“…On the other hand, high ratio of surfactant may affect the system's compatibility of formulation with the skin [144] . Recently, multiple W/O/W nanoemulsions as superior delivery system for acyclovir have been proposed [145].…”

Section: Micro-and Nano-emulsionsmentioning

confidence: 99%

(Phospho)lipid-based Nanosystems for Skin Administration

Vanić¹,

Holæter²,

Škalko‐Basnet

2015

CPD

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Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability to assure the controlled drug release to the skin and skin appendages, drug targeting and safety. Different types of liposomes, biphasic vesicles, particulate lipid-based nanosystems and micro-and nano-emulsions are discussed in more details. Extensive research in preclinical studies has shown that numerous parameters including the composition, size, surface properties and their combinations affect the deposition and/or penetration of carrier-associated drug into/through the skin, and consequently determine the therapeutic effect. The superiority of the most promising nanopharmaceuticals has been confirmed in clinical studies. We have selected several common skin disorders and provided overview over promises of nanodermatology in antimicrobial skin therapy, anti-acne treatment, skin oncology, gene delivery and vaccines. We addressed the potential toxicity and irritation issues and provided an overview of registered lipid-based products

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“…To describe a few, Hillaireau et al encapsulated azidothymidine triphosphate and cidofovir in poly(isobutyl cyanoacrylate) nanocapsules [ 47 ], whereas Yu et al demonstrated reduced skin irritancy and signifi cant replication inhibition of HSV-1 with penciclovir-loaded microemulsion (droplet size ~36.5 nm) as compared to the marketed cream [ 37 ]. Further, the W/O/W nanoemulsion (NE) of acyclovir (droplet size ~100 nm) was reported to be stable and interestingly in vitro skin permeation studies demonstrated 1.3-fold higher fl ux as compared to acyclovir aqueous solution [ 35 ].…”

Section: Antiviral Nanotherapeuticsmentioning

confidence: 99%