Optimisation of powders for pulmonary delivery using supercritical fluid technology

Rehman, Mahboob; Shekunov, Boris Y.; York, Peter; Lechuga‐Ballesteros, David; Miller, Danforth P.; Tan, Trixie; Colthorpe, Paul

doi:10.1016/j.ejps.2004.02.001

Cited by 92 publications

(46 citation statements)

References 14 publications

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“…Examples are co-crystallization of drugs and excipients by standard spray drying [76], spray drying using supercritical enhanced atomization [77], or supercritical fluids crystallization (SEDs: solution-enhanced dispersion by supercritical fluids) [72,78]. Such particles generally exhibit improved dispersion performance [79,80]. Another approach to obtain better dispersion performance of adhesive mixtures finds its origin in the work of Staniforth [81].…”

Section: 'Repair Actions' For Design Weaknesses Of Early Dpi Conceptsmentioning

confidence: 99%

Dry powder inhalation: past, present and future

Boer

Hagedoorn

Hoppentocht

et al. 2016

Expert Opinion on Drug Delivery

226

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Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked efficient dispersion principles. Therefore, particle engineering and powder processing are increasingly applied to achieve acceptable lung deposition with these poorly designed inhalers. Areas covered: The consequences of the choices made for early DPI development with respect of efficacy, production costs and safety and the tremendous amount of energy put into understanding and controlling the dispersion performance of adhesive mixtures are discussed. Also newly developed particle manufacturing and powder formulation processes are presented as well as the challenges, objectives, and new tools available for future DPI design. Expert opinion: Improved inhaler design is desired to make DPIs for future applications cost-effective and safe. With an increasing interest in high dose drug delivery, vaccination and systemic delivery via the lungs, innovative formulation technologies alone may not be sufficient. Safety is served by increasing patient adherence to the therapy, minimizing the use of unnecessary excipients and designing simple and self-intuitive inhalers, which give good feedback to the patient about the inhalation maneuver. For some applications, like vaccination and delivery of hygroscopic formulations, disposable inhalers may be preferred. ARTICLE HISTORY

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Section: 'Repair Actions' For Design Weaknesses Of Early Dpi Conceptsmentioning

confidence: 99%

Dry powder inhalation: past, present and future

Boer

Hagedoorn

Hoppentocht

et al. 2016

Expert Opinion on Drug Delivery

226

View full text Add to dashboard Cite

show abstract

“…This method has demonstrated a wide range of application in producing pulmonary inhalable formulations. 23,161,162 Supercritical fluid technology can be divided into several classes. The most important two are supercritical antisolvent precipitation (SAS) 163,164 and supercritical fluid extraction of emulsions (SFEE).…”

Section: Supercritical Fluid Technology (Scf)mentioning

confidence: 99%

Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

409

269

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“…However, high-energy milling techniques, such as air jet milling, are far from ideal as the products formed are often cohesive, highly electrostatically charged, and difficult to process downstream. 10 Considering the limitations of this technique in controlling particle properties, including size distribution, shape, density, and surface characteristics, various techniques have been explored as alternative methods for the preparation of powders with enhanced dispersion properties.…”

Section: Introductionmentioning

confidence: 99%