Optimising the utility of pleural fluid adenosine deaminase for the diagnosis of adult tuberculous pleural effusion in Hong Kong

Kc, Chang; Chan, M. A.; Leung, WM; Kong, FY; Mak, Chloe Miu; Chen, Sammy Pl; Yu, WC

doi:10.12809/hkmj176238

Cited by 14 publications

(18 citation statements)

References 20 publications

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“…We observed a good correlation between the two analytical systems (r 2 =0.88; t test for correlation coefficient, P<0.001), even though bias was observed (~16 %). After using the cut-off value proposed by Chang et al, 1 we observed only one misclassification between the two analytical systems (Fig).…”

Section: Pleural Adenosine Deaminase Cut-off Value For the Diagnosis mentioning

confidence: 76%

“…In conclusion, we consider the cut-off value proposed by Chang et al 1 for TBPE diagnosis to be appropriate on whichever analytical system the Diazyme assay is used.…”

Section: Pleural Adenosine Deaminase Cut-off Value For the Diagnosis mentioning

confidence: 99%

“…To the Editor-We read with interest the article by Chang et al 1 In the diagnosis of tuberculous pleural effusion (TBPE), they established that 26.5 U/L is the optimal cut-off value for pleural fluid adenosine deaminase activity when using the systems. Therefore, one can ask the question: does the cut-off value differ according to the analytical system?…”

Section: Pleural Adenosine Deaminase Cut-off Value For the Diagnosis mentioning

confidence: 99%

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Pleural adenosine deaminase cut-off value for the diagnosis of tuberculous pleural effusion using the Diazyme assay

Servonnet¹,

Frédéric²,

Fargeau³

et al. 2018

Hong Kong Med J

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Section: Pleural Adenosine Deaminase Cut-off Value For the Diagnosis mentioning

confidence: 76%

“…In conclusion, we consider the cut-off value proposed by Chang et al 1 for TBPE diagnosis to be appropriate on whichever analytical system the Diazyme assay is used.…”

Section: Pleural Adenosine Deaminase Cut-off Value For the Diagnosis mentioning

confidence: 99%

Section: Pleural Adenosine Deaminase Cut-off Value For the Diagnosis mentioning

confidence: 99%

See 1 more Smart Citation

Pleural adenosine deaminase cut-off value for the diagnosis of tuberculous pleural effusion using the Diazyme assay

Servonnet¹,

Frédéric²,

Fargeau³

et al. 2018

Hong Kong Med J

View full text Add to dashboard Cite

“…To the Editor-I read with interest the paper by Chang et al 1 on the utility of pleural fluid ADA (pADA) for diagnosis of tuberculous pleural effusion (TBPE) in Hong Kong. Their effort in establishing the best cut-off pADA level based on a large local cohort is to be commended.…”

mentioning

confidence: 99%

“…Pleural biopsy (PLBx) showed classical granulomatous inflammation and both pleural fluid and sputum were positive on culture for tuberculosis. According to Chang et al's paper, 1 TBPE would have been excluded as a diagnosis based on his suggested pADA value.…”

mentioning

confidence: 99%

Early diagnosis of tuberculous pleural effusion: apart from pleural fluid adenosine deaminase, pleural biopsy still has a role

Wong

2018

Hong Kong Med J

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Clinical characteristics and potential indicators for definite diagnosis of tuberculous pleural effusion

Xiong

Mao

Shen

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Aims: The study aimed to investigate the clinical characteristics of patients with pleural effusion (PE), and explore the effective indicators for definite diagnosis of tuberculous pleural effusion (TBPE). Methods: The adult patients with the presence of PE were enrolled. All the patients received pleural fluid Mycobacterium tuberculosis DNA detection, ADA activity measure and blood T-SPOT.TB test. The clinical characteristics and examination results were recorded. Results: A total of 77 PE patients, including 30 (38.96%) TBPE, 19 (24.67%) malignant PE, 6 (7.79%) empyema, 10 (12.99%) parapneumonic effusion and 12 (15.58%) miscellaneous causes, were enrolled. The diagnostic sensitivity and specificity of pleural fluid M. tuberculosis DNA detection were 33.3% and 100%, respectively. The diagnostic parameters of pleural fluid ADA for TBPE were as follows: sensitivity 50% and specificity 78.7%. In PE cases with pleural fluid lactate dehydrogenase (LDH) more than 500 U/L, the diagnostic values of DNA detection and ADA activity were enhanced, and DNA detection was superior to ADA activity. In addition, the ratio of blood T-STOP.TB A þ B to lymphocyte was a potential diagnostic biomarker for TBPE with the sensitivity of 83.3% and the specificity of 66.0%. Conclusion: The clinical significance of pleural fluid M. tuberculosis DNA detection is superior to ADA activity in the diagnosis of TBPE, especially in PE cases with LDH value more than 500 U/L. The ratio of blood T-STOP.TB A þ B to lymphocyte is a potential indicator for definite diagnosis of TBPE, with high sensitivity.

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Optimising the utility of pleural fluid adenosine deaminase for the diagnosis of adult tuberculous pleural effusion in Hong Kong

Cited by 14 publications

References 20 publications

Pleural adenosine deaminase cut-off value for the diagnosis of tuberculous pleural effusion using the Diazyme assay

Pleural adenosine deaminase cut-off value for the diagnosis of tuberculous pleural effusion using the Diazyme assay

Early diagnosis of tuberculous pleural effusion: apart from pleural fluid adenosine deaminase, pleural biopsy still has a role

Clinical characteristics and potential indicators for definite diagnosis of tuberculous pleural effusion

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