Objective
Depression has been associated with vascular dysfunction, which may be of particular relevance in pregnancy. Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine play a critical role in vascular function. The objective of this study was to investigate differences in ADMA, SDMA, and L-arginine among pregnant women with major depression compared to pregnant women without depression.
Methods
A case-control study was conducted in 21 depressed pregnant women and 42 matched controls. Maternal plasma ADMA, SDMA, and L-arginine were quantified, as well as C-reactive protein (CRP), urine excretion of ADMA, SDMA, L-arginine, and Arginase I.
Results
Plasma L-arginine and ADMA levels were significantly lower in the first trimester in women with depression (37.0±9.2 and 0.298±0.06μmol/L, mean± standard deviation [SD], respectively) compared to matched controls (42.1±11.4 and 0.336±0.08μmol/L, p=0.004 and p=0.002 respectively) and across pregnancy (p<0.001 both). Depressed pregnant women had higher levels of plasma CRP (7.5±3.7 vs. 5.1±4.0 μg/mL, p=0.027), but no differences urine excretion of ADMA, SDMA, or L-arginine, or plasma levels of Arginase I (p values > 0.10).
Conclusions
Pregnant women with depression evidence lower plasma levels of L-arginine and ADMA. These differences are not explained by urinary excretion or Arginase I levels. The mechanism responsible for the observed differences in depressed pregnant women requires further research.